Papers of note in Science Translational Medicine 9 (402)

Leslie K. Ferrarelli

doi:10.1126/scisignal.aao6262

This week’s articles describe a way to prevent a major side effect of chemotherapy, paths of endocrine therapy resistance in breast cancer, and a new treatment for type 1 diabetes.

CANCER

Rock-a-bye bone marrow

Taylor et al. report that inhibitors of the kinase FLT3 might be used to protect the bone marrow during chemotherapy.

A patient look at cancer resistance

Giltnane et al. analyze patients’ breast tumors after estrogen-blocking therapy and find new targets to prevent drug resistance.

AUTOIMMUNITY

Peptide therapy for diabetes

Alhadj Ali et al. show that an immunogenic proinsulin peptide modified T cell responses without disrupting β cell function in patients with type 1 diabetes.

Highlighted Articles

1. S. J. Taylor,
2. J. M. Duyvestyn,
3. S. A. Dagger,
4. E. J. Dishington,
5. C. A. Rinaldi,
6. O. M. Dovey,
7. G. S. Vassiliou,
8. C. S. Grove,
9. W. Y. Langdon
, Preventing chemotherapy-induced myelosuppression by repurposing the FLT3 inhibitor quizartinib. Sci. Transl. Med. 9, eaam8060 (2017).
OpenUrl Abstract/FREE Full Text
1. J. M. Giltnane,
2. K. E. Hutchinson,
3. T. P. Stricker,
4. L. Formisano,
5. C. D. Young,
6. M. V. Estrada,
7. M. J. Nixon,
8. L. Du,
9. V. Sanchez,
10. P. G. Ericsson,
11. M. G. Kuba,
12. M. E. Sanders,
13. X. J. Mu,
14. E. M. Van Allen,
15. N. Wagle,
16. I. A. Mayer,
17. V. Abramson,
18. H. Gόmez,
19. M. Rizzo,
20. W. Toy,
21. S. Chandarlapaty,
22. E. L. Mayer,
23. J. Christiansen,
24. D. Murphy,
25. K. Fitzgerald,
26. K. Wang,
27. J. S. Ross,
28. V. A. Miller,
29. P. J. Stephens,
30. R. Yelensky,
31. L. Garraway,
32. Y. Shyr,
33. I. Meszoely,
34. J. M. Balko,
35. C. L. Arteaga
, Genomic profiling of ER⁺ breast cancers after short-term estrogen suppression reveals alterations associated with endocrine resistance. Sci. Transl. Med. 9, eaai7993 (2017).
OpenUrl Abstract/FREE Full Text
1. M. Alhadj Ali,
2. Y.-F. Liu,
3. S. Arif,
4. D. Tatovic,
5. H. Shariff,
6. V. B. Gibson,
7. N. Yusuf,
8. R. Baptista,
9. M. Eichmann,
10. N. Petrov,
11. S. Heck,
12. J. H. M. Yang,
13. T. I. M. Tree,
14. I. Pujol-Autonell,
15. L. Yeo,
16. L. R. Baumard,
17. R. Stenson,
18. A. Howell,
19. A. Clark,
20. Z. Boult,
21. J. Powrie,
22. L. Adams,
23. F. S. Wong,
24. S. Luzio,
25. G. Dunseath,
26. K. Green,
27. A. O’Keefe,
28. G. Bayly,
29. N. Thorogood,
30. R. Andrews,
31. N. Leech,
32. F. Joseph,
33. S. Nair,
34. S. Seal,
35. H. Cheung,
36. C. Beam,
37. R. Hills,
38. M. Peakman,
39. C. M. Dayan
, Metabolic and immune effects of immunotherapy with proinsulin peptide in human new-onset type 1 diabetes. Sci. Transl. Med. 9, eaaf7779 (2017).
OpenUrl Abstract/FREE Full Text

View Abstract

This week’s articles describe a way to prevent a major side effect of chemotherapy, paths of endocrine therapy resistance in breast cancer, and a new treatment for type 1 diabetes.

[1] S. J. Taylor,
J. M. Duyvestyn,
S. A. Dagger,
E. J. Dishington,
C. A. Rinaldi,
O. M. Dovey,
G. S. Vassiliou,
C. S. Grove,
W. Y. Langdon
, Preventing chemotherapy-induced myelosuppression by repurposing the FLT3 inhibitor quizartinib. Sci. Transl. Med. 9, eaam8060 (2017).
OpenUrl Abstract/FREE Full Text

[2] S. J. Taylor,

[3] J. M. Duyvestyn,

[4] S. A. Dagger,

[5] E. J. Dishington,

[6] C. A. Rinaldi,

[7] O. M. Dovey,

[8] G. S. Vassiliou,

[9] C. S. Grove,

[10] W. Y. Langdon

[11] J. M. Giltnane,
K. E. Hutchinson,
T. P. Stricker,
L. Formisano,
C. D. Young,
M. V. Estrada,
M. J. Nixon,
L. Du,
V. Sanchez,
P. G. Ericsson,
M. G. Kuba,
M. E. Sanders,
X. J. Mu,
E. M. Van Allen,
N. Wagle,
I. A. Mayer,
V. Abramson,
H. Gόmez,
M. Rizzo,
W. Toy,
S. Chandarlapaty,
E. L. Mayer,
J. Christiansen,
D. Murphy,
K. Fitzgerald,
K. Wang,
J. S. Ross,
V. A. Miller,
P. J. Stephens,
R. Yelensky,
L. Garraway,
Y. Shyr,
I. Meszoely,
J. M. Balko,
C. L. Arteaga
, Genomic profiling of ER⁺ breast cancers after short-term estrogen suppression reveals alterations associated with endocrine resistance. Sci. Transl. Med. 9, eaai7993 (2017).
OpenUrl Abstract/FREE Full Text

[12] J. M. Giltnane,

[13] K. E. Hutchinson,

[14] T. P. Stricker,

[15] L. Formisano,

[16] C. D. Young,

[17] M. V. Estrada,

[18] M. J. Nixon,

[19] L. Du,

[20] V. Sanchez,

[21] P. G. Ericsson,

[22] M. G. Kuba,

[23] M. E. Sanders,

[24] X. J. Mu,

[25] E. M. Van Allen,

[26] N. Wagle,

[27] I. A. Mayer,

[28] V. Abramson,

[29] H. Gόmez,

[30] M. Rizzo,

[31] W. Toy,

[32] S. Chandarlapaty,

[33] E. L. Mayer,

[34] J. Christiansen,

[35] D. Murphy,

[36] K. Fitzgerald,

[37] K. Wang,

[38] J. S. Ross,

[39] V. A. Miller,

[40] P. J. Stephens,

[41] R. Yelensky,

[42] L. Garraway,

[43] Y. Shyr,

[44] I. Meszoely,

[45] J. M. Balko,

[46] C. L. Arteaga

[47] M. Alhadj Ali,
Y.-F. Liu,
S. Arif,
D. Tatovic,
H. Shariff,
V. B. Gibson,
N. Yusuf,
R. Baptista,
M. Eichmann,
N. Petrov,
S. Heck,
J. H. M. Yang,
T. I. M. Tree,
I. Pujol-Autonell,
L. Yeo,
L. R. Baumard,
R. Stenson,
A. Howell,
A. Clark,
Z. Boult,
J. Powrie,
L. Adams,
F. S. Wong,
S. Luzio,
G. Dunseath,
K. Green,
A. O’Keefe,
G. Bayly,
N. Thorogood,
R. Andrews,
N. Leech,
F. Joseph,
S. Nair,
S. Seal,
H. Cheung,
C. Beam,
R. Hills,
M. Peakman,
C. M. Dayan
, Metabolic and immune effects of immunotherapy with proinsulin peptide in human new-onset type 1 diabetes. Sci. Transl. Med. 9, eaaf7779 (2017).
OpenUrl Abstract/FREE Full Text

[48] M. Alhadj Ali,

[49] Y.-F. Liu,

[50] S. Arif,

[51] D. Tatovic,

[52] H. Shariff,

[53] V. B. Gibson,

[54] N. Yusuf,

[55] R. Baptista,

[56] M. Eichmann,

[57] N. Petrov,

[58] S. Heck,

[59] J. H. M. Yang,

[60] T. I. M. Tree,

[61] I. Pujol-Autonell,

[62] L. Yeo,

[63] L. R. Baumard,

[64] R. Stenson,

[65] A. Howell,

[66] A. Clark,

[67] Z. Boult,

[68] J. Powrie,

[69] L. Adams,

[70] F. S. Wong,

[71] S. Luzio,

[72] G. Dunseath,

[73] K. Green,

[74] A. O’Keefe,

[75] G. Bayly,

[76] N. Thorogood,

[77] R. Andrews,

[78] N. Leech,

[79] F. Joseph,

[80] S. Nair,

[81] S. Seal,

[82] H. Cheung,

[83] C. Beam,

[84] R. Hills,

[85] M. Peakman,

[86] C. M. Dayan

Papers of note in Science Translational Medicine 9 (402)

Highlighted Articles

Science Signaling

Article Tools