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Papers of note in Science Translational Medicine 9 (403)

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Science Signaling  22 Aug 2017:
Vol. 10, Issue 493, eaao7008
DOI: 10.1126/scisignal.aao7008

This week’s articles describe ways to treat neurodegenerative and neurodevelopmental diseases.


A new therapeutic target zips into view

Le Pichon et al. discover that inhibition of signaling from dual leucine zipper kinase (DLK) to c-Jun N-terminal kinase (JNK) promotes neuronal survival and slows progression in mouse models of amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease.

A positive approach to Rett syndrome

Gogliotti et al. report that restoring activity of the metabotropic glutamate receptor 7 (mGlu7) with a positive allosteric modulator improves synaptic plasticity and cognition in mouse models of the neurodevelopmental disorder Rett syndrome.

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