Research ArticleCancer
Cancer-associated arginine-to-histidine mutations confer a gain in pH sensing to mutant proteins
- View ORCID ProfileKatharine A. White1,
- View ORCID ProfileDiego Garrido Ruiz2,
- View ORCID ProfileZachary A. Szpiech3,
- View ORCID ProfileNicolas B. Strauli3,
- Ryan D. Hernandez3,4,5,
- View ORCID ProfileMatthew P. Jacobson2, and
- View ORCID ProfileDiane L. Barber1,*
- 1Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA.
- 2Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94143, USA.
- 3Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94143, USA.
- 4Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
- 5Institute for Human Genetics, University of California, San Francisco, San Francisco, CA 94143, USA.
- ↵*Corresponding author. Email: diane.barber{at}ucsf.edu
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Science Signaling 05 Sep 2017:
Vol. 10, Issue 495, eaam9931
DOI: 10.1126/scisignal.aam9931
Vol. 10, Issue 495, eaam9931
DOI: 10.1126/scisignal.aam9931
Katharine A. White
1Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA.
Diego Garrido Ruiz
2Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94143, USA.
Zachary A. Szpiech
3Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94143, USA.
Nicolas B. Strauli
3Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94143, USA.
Ryan D. Hernandez
3Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94143, USA.
4Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
5Institute for Human Genetics, University of California, San Francisco, San Francisco, CA 94143, USA.
Matthew P. Jacobson
2Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94143, USA.
Diane L. Barber
1Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA.
