This week’s articles describe an alternative mechanism of secretion that is deployed by intestinal cells in the presence of pathogens; how the immune system protects the lungs from inhaled fungal spores; and metabolic reprogramming of tissue-resident antigen-presenting cells in the lung.
HOST-PATHOGEN INTERACTIONS
Foiling bad bugs' sneaky tricks
Bel et al. found that during pathogen-induced cellular stress, Paneth cells reroute a key antimicrobial protein through an autophagy-based secretion pathway (see also Kaser and Blumberg).
Survivin' neutrophil surveillance
Shlezinger et al. discovered that mold spores do not become invasive after inhalation by humans because neutrophils induce their death at germination.
INFLAMMATION
Metabolic programming of tissue APCs
Sinclair et al. report that metabolic adaptation of antigen-presenting cells in the lung reprograms lung dendritic cells and modulates allergic inflammation (see also Wiesner and Klein).