Contents
19 September 2017
Vol 10, Issue 497
Vol 10, Issue 497
Research Articles
- The RNA-editing enzyme ADAR promotes lung adenocarcinoma migration and invasion by stabilizing FAK
Editing of FAK mRNA by the enzyme ADAR in lung adenocarcinoma cells promotes migration and invasion.
- Microtubule structures underlying the sarcoplasmic reticulum support peripheral coupling sites to regulate smooth muscle contractility
Microtubules position ion channels close to each other to ensure autoregulation of vascular tone in cerebral arteries.
- TALK-1 channels control β cell endoplasmic reticulum Ca2+ homeostasis
An ER-localized K+ channel could be targeted to suppress ER stress in diabetic pancreatic β cells.
Editors' Choice
- Highlight: RNA-binding proteins in cancer
ADAR promotes lung adenocarcinoma migration and invasion through stabilization of FAK.
- PKD and inflammation
Protein kinase D signaling at the Golgi is required for activation of the NLRP3 inflammasome.
- Papers of note in Science 357 (6356)
This week’s articles explain how plants establish and maintain an epigenetic memory of cold temperature and review how the engineering of channelrhodopsins as research tools has elucidated the biochemical properties of these light-activated ion channels.
- Papers of note in Science Translational Medicine 9 (407)
This week’s articles show that blocking a prometastatic process unintentionally impairs immunotherapy and report new therapeutic targets in type 2 diabetes and asthmatic lung disease.
- Papers of note in Nature 549 (7671)
This week’s articles highlight the immune response to intestinal helminth parasites and an mRNA modification that determines cell fate.
About The Cover
Online Cover This week features a Research Article that describes how an RNA editing enzyme promotes the progression of some lung cancers by stabilizing the RNA that encodes the cell migration–associated kinase FAK. The image shows staining for ADAR in a lung adenocarcinoma sample. [Image: Amin et al., Science Signaling]