Research ArticleCancer

The RNA-editing enzyme ADAR promotes lung adenocarcinoma migration and invasion by stabilizing FAK

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Science Signaling  19 Sep 2017:
Vol. 10, Issue 497, eaah3941
DOI: 10.1126/scisignal.aah3941

Metastatic edits to FAK

Drugs that inhibit cell migration pathways, such as that mediated by the kinase FAK, may prevent metastasis and improve long-term survival in cancer patients. Amin et al. found that the RNA-editing enzyme ADAR supports the activity of FAK. In lung adenocarcinoma cells, ADAR bound to and edited FAK mRNA in a manner that improved its stability, thus increasing the abundance of FAK protein and enhancing the migration of these cells. High ADAR expression was a poor prognostic indicator in patients. These findings suggest that inhibiting FAK may be therapeutic in patients with ADAR-positive lung adenocarcinoma.

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