This week’s articles highlight the immune response to intestinal helminth parasites and an mRNA modification that determines cell fate.
HOST-PATHOGEN INTERACTIONS
Enteric neurons sound the alarm
Cardoso et al. and Klose et al. found that the presence of helminth parasites causes enteric neurons to release a neuropeptide that stimulates innate lymphoid cells to initiate a type 2 inflammatory response.
DEVELOPMENTAL BIOLOGY
mRNA modification determines cell fate
Zhang et al. report that a specific biochemical modification of mRNAs influences the specification of the hematopoietic lineage in zebrafish embryos by affecting Notch-mediated cell fate determination.