Papers of note in Nature 549 (7671)

Annalisa M. VanHook

doi:10.1126/scisignal.aap9538

This week’s articles highlight the immune response to intestinal helminth parasites and an mRNA modification that determines cell fate.

HOST-PATHOGEN INTERACTIONS

Enteric neurons sound the alarm

Cardoso et al. and Klose et al. found that the presence of helminth parasites causes enteric neurons to release a neuropeptide that stimulates innate lymphoid cells to initiate a type 2 inflammatory response.

DEVELOPMENTAL BIOLOGY

mRNA modification determines cell fate

Zhang et al. report that a specific biochemical modification of mRNAs influences the specification of the hematopoietic lineage in zebrafish embryos by affecting Notch-mediated cell fate determination.

Highlighted Articles

1. V. Cardoso,
2. J. Chesné,
3. H. Ribeiro,
4. B. García-Cassani,
5. T. Carvalho,
6. T. Bouchery,
7. K. Shah,
8. N. L. Barbosa-Morais,
9. N. Harris,
10. H. Veiga-Fernandes
, Neuronal regulation of type 2 innate lymphoid cells via neuromedin U. Nature 549, 277–281 (2017).
OpenUrl
1. C. S. N. Klose,
2. T. Mahlakõiv,
3. J. B. Moeller,
4. L. C. Rankin,
5. A.-L. Flamar,
6. H. Kabata,
7. L. A. Monticelli,
8. S. Moriyama,
9. G. G. Putzel,
10. N. Rakhilin,
11. X. Shen,
12. E. Kostenis,
13. G. M. König,
14. T. Senda,
15. D. Carpenter,
16. D. L. Farber,
17. D. Artis
, The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation. Nature 549, 282–286 (2017).
OpenUrl
1. C. Zhang,
2. Y. Chen,
3. B. Sun,
4. L. Wang,
5. Y. Yang,
6. D. Ma,
7. J. Lv,
8. J. Heng,
9. Y. Ding,
10. Y. Xue,
11. X. Lu,
12. W. Xiao,
13. Y.-G. Yang,
14. F. Liu
, m⁶A modulates haematopoietic stem and progenitor cell specification. Nature 549, 273–276 (2017).
OpenUrl

View Abstract

[1] V. Cardoso,
J. Chesné,
H. Ribeiro,
B. García-Cassani,
T. Carvalho,
T. Bouchery,
K. Shah,
N. L. Barbosa-Morais,
N. Harris,
H. Veiga-Fernandes
, Neuronal regulation of type 2 innate lymphoid cells via neuromedin U. Nature 549, 277–281 (2017).
OpenUrl

[2] V. Cardoso,

[3] J. Chesné,

[4] H. Ribeiro,

[5] B. García-Cassani,

[6] T. Carvalho,

[7] T. Bouchery,

[8] K. Shah,

[9] N. L. Barbosa-Morais,

[10] N. Harris,

[11] H. Veiga-Fernandes

[12] C. S. N. Klose,
T. Mahlakõiv,
J. B. Moeller,
L. C. Rankin,
A.-L. Flamar,
H. Kabata,
L. A. Monticelli,
S. Moriyama,
G. G. Putzel,
N. Rakhilin,
X. Shen,
E. Kostenis,
G. M. König,
T. Senda,
D. Carpenter,
D. L. Farber,
D. Artis
, The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation. Nature 549, 282–286 (2017).
OpenUrl

[13] C. S. N. Klose,

[14] T. Mahlakõiv,

[15] J. B. Moeller,

[16] L. C. Rankin,

[17] A.-L. Flamar,

[18] H. Kabata,

[19] L. A. Monticelli,

[20] S. Moriyama,

[21] G. G. Putzel,

[22] N. Rakhilin,

[23] X. Shen,

[24] E. Kostenis,

[25] G. M. König,

[26] T. Senda,

[27] D. Carpenter,

[28] D. L. Farber,

[29] D. Artis

[30] C. Zhang,
Y. Chen,
B. Sun,
L. Wang,
Y. Yang,
D. Ma,
J. Lv,
J. Heng,
Y. Ding,
Y. Xue,
X. Lu,
W. Xiao,
Y.-G. Yang,
F. Liu
, m⁶A modulates haematopoietic stem and progenitor cell specification. Nature 549, 273–276 (2017).
OpenUrl

[31] C. Zhang,

[32] Y. Chen,

[33] B. Sun,

[34] L. Wang,

[35] Y. Yang,

[36] D. Ma,

[37] J. Lv,

[38] J. Heng,

[39] Y. Ding,

[40] Y. Xue,

[41] X. Lu,

[42] W. Xiao,

[43] Y.-G. Yang,

[44] F. Liu

Papers of note in Nature 549 (7671)

Highlighted Articles

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