Contents
26 September 2017
Vol 10, Issue 498
Vol 10, Issue 498
Research Articles
- Tim-3 signaling in peripheral NK cells promotes maternal-fetal immune tolerance and alleviates pregnancy loss
A subset of natural killer cells suppresses the mother’s immune system to protect the fetus.
- Dimerization of the adaptor Gads facilitates antigen receptor signaling by promoting the cooperative binding of Gads to the adaptor LAT
Constitutive dimerization of an adaptor molecule enables it to selectively amplify signaling by binding cooperatively to signaling complexes downstream of antigen receptors.
Research Resource
- Evaluation of the selectivity and sensitivity of isoform- and mutation-specific RAS antibodies
Validation studies reveal the reliability of isoform- and mutation-specific anti-RAS antibodies.
Editors' Choice
- Protecting cognition from antipsychotics
Inhibiting a mechanism that mediates cognitive deficits caused by antipsychotic drugs may improve clinical outcomes for schizophrenia patients.
- Papers of note in Science 357 (6357)
This week’s articles identify a mutation in the acetylcholine receptor that protects poison frogs from the neurotoxin that they produce; explain a key difference between neurons from Parkinson’s patients and those from mouse models of the disease; and review the intermolecular interactions that drive the formation of membraneless intracellular compartments.
- Papers of note in Science Translational Medicine 9 (408)
This week’s articles describe new therapeutic strategies for cancer, lung inflammation, and graft-versus-host disease.
- Papers of note in Nature 549 (7672)
This week’s articles highlight the role of AMPA receptor diffusion in long-term potentiation; a mutation in an embryonic cell lineage that leads to adult neurodegeneration; the structural basis of cGAS activation; a posttranslational modification of the melanocortin-1 receptor that protects against melanoma; and factors from maternal cells that determine whether daughter cells will proliferate.
About The Cover
Online Cover This week features a Research Article that highlights a role for a specific subset of natural killer (NK) cells in maintaining maternal-fetal tolerance and reducing fetal loss. NK cells that had the receptor Tim-3 on the cell surface were increased in number during the first trimester and were associated with an anti-inflammatory and immunosuppressive environment. Thus, this NK cell subset may serve as a biomarker for the prediction of recurrent miscarriage in humans. [Image: iStock.com/Tigatelu]