Dimerization of the adaptor Gads facilitates antigen receptor signaling by promoting the cooperative binding of Gads to the adaptor LAT

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  Dimerization of the adaptor Gads facilitates antigen receptor signaling by promoting the cooperative binding of Gads to the adaptor LAT

  By Sigalit Sukenik, Maria P. Frushicheva, Cecilia Waknin-Lellouche, Enas Hallumi, Talia Ifrach, Rose Shalah, Dvora Beach, Reuven Avidan, Ilana Oz, Evgeny Libman, Ami Aronheim, Oded Lewinson, Deborah Yablonski

  Science Signaling26 Sep 2017

  Constitutive dimerization of an adaptor molecule enables it to selectively amplify signaling by binding cooperatively to signaling complexes downstream of antigen receptors.

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  Dimerization of the adaptor Gads facilitates antigen receptor signaling by promoting the cooperative binding of Gads to the adaptor LAT

  By Sigalit Sukenik, Maria P. Frushicheva, Cecilia Waknin-Lellouche, Enas Hallumi, Talia Ifrach, Rose Shalah, Dvora Beach, Reuven Avidan, Ilana Oz, Evgeny Libman, Ami Aronheim, Oded Lewinson, Deborah Yablonski

  Science Signaling26 Sep 2017

  Constitutive dimerization of an adaptor molecule enables it to selectively amplify signaling by binding cooperatively to signaling complexes downstream of antigen receptors.

  • Supplementary Materials

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