Research ArticleImmunology
Dimerization of the adaptor Gads facilitates antigen receptor signaling by promoting the cooperative binding of Gads to the adaptor LAT
- Sigalit Sukenik1,
- Maria P. Frushicheva2,
- Cecilia Waknin-Lellouche1,
- Enas Hallumi1,
- Talia Ifrach1,
- Rose Shalah1,
- Dvora Beach1,
- Reuven Avidan1,
- Ilana Oz1,
- Evgeny Libman1,*,
- Ami Aronheim3,
- Oded Lewinson4, and
- Deborah Yablonski1,†
- 1Department of Immunology, Ruth and Bruce Rappaport Faculty of Medicine, Technion—Israel Institute of Technology, Haifa 3525433, Israel.
- 2Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
- 3Department of Cell Biology and Cancer Science, Ruth and Bruce Rappaport Faculty of Medicine, Technion—Israel Institute of Technology, Haifa 3525433, Israel.
- 4Department of Biochemistry, Ruth and Bruce Rappaport Faculty of Medicine, Technion—Israel Institute of Technology, Haifa 3525433, Israel.
- ↵†Corresponding author. Email: debya{at}tx.technion.ac.il
↵* Present address: MediWound Ltd., Yavne, Israel.
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Science Signaling 26 Sep 2017:
Vol. 10, Issue 498, eaal1482
DOI: 10.1126/scisignal.aal1482
Vol. 10, Issue 498, eaal1482
DOI: 10.1126/scisignal.aal1482
Sigalit Sukenik
Department of Immunology, Ruth and Bruce Rappaport Faculty of Medicine, Technion—Israel Institute of Technology, Haifa 3525433, Israel.
Maria P. Frushicheva
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Cecilia Waknin-Lellouche
Department of Immunology, Ruth and Bruce Rappaport Faculty of Medicine, Technion—Israel Institute of Technology, Haifa 3525433, Israel.
Enas Hallumi
Department of Immunology, Ruth and Bruce Rappaport Faculty of Medicine, Technion—Israel Institute of Technology, Haifa 3525433, Israel.
Talia Ifrach
Department of Immunology, Ruth and Bruce Rappaport Faculty of Medicine, Technion—Israel Institute of Technology, Haifa 3525433, Israel.
Rose Shalah
Department of Immunology, Ruth and Bruce Rappaport Faculty of Medicine, Technion—Israel Institute of Technology, Haifa 3525433, Israel.
Dvora Beach
Department of Immunology, Ruth and Bruce Rappaport Faculty of Medicine, Technion—Israel Institute of Technology, Haifa 3525433, Israel.
Reuven Avidan
Department of Immunology, Ruth and Bruce Rappaport Faculty of Medicine, Technion—Israel Institute of Technology, Haifa 3525433, Israel.
Ilana Oz
Department of Immunology, Ruth and Bruce Rappaport Faculty of Medicine, Technion—Israel Institute of Technology, Haifa 3525433, Israel.
Evgeny Libman
Department of Immunology, Ruth and Bruce Rappaport Faculty of Medicine, Technion—Israel Institute of Technology, Haifa 3525433, Israel.
Ami Aronheim
Department of Cell Biology and Cancer Science, Ruth and Bruce Rappaport Faculty of Medicine, Technion—Israel Institute of Technology, Haifa 3525433, Israel.
Oded Lewinson
Department of Biochemistry, Ruth and Bruce Rappaport Faculty of Medicine, Technion—Israel Institute of Technology, Haifa 3525433, Israel.
Deborah Yablonski
Department of Immunology, Ruth and Bruce Rappaport Faculty of Medicine, Technion—Israel Institute of Technology, Haifa 3525433, Israel.
