Contents
03 October 2017
Vol 10, Issue 499
Vol 10, Issue 499
Research Articles
- Inhibition of the oncogenic fusion protein EWS-FLI1 causes G2-M cell cycle arrest and enhanced vincristine sensitivity in Ewing’s sarcoma
A drug sensitizes Ewing’s sarcoma cells to chemotherapy by inducing mitotic arrest and priming the cells for apoptosis.
- Genome-wide functional analysis reveals central signaling regulators of lymphatic endothelial cell migration and remodeling
The signaling proteins and pathways involved in lymphatic endothelial cell migration are identified through a functional screen.
Editors' Choice
- Pathogen-induced mitochondrial fragmentation
Legionella pneumophila promotes activation of the mitochondrial fission machinery to metabolically reprogram host macrophages.
- Papers of note in Science 357 (6358)
This week’s article shows that the release of oxytocin in the ventral tegmental area influences sociability in mice by stimulating dopaminergic neurons that project to the brain’s reward center.
- Papers of note in Science Translational Medicine 9 (409)
This week’s articles describe a stem cell–based therapy for chronic kidney disease and targets for treating diabetic nerve pain and acute respiratory distress in critically ill patients.
- Papers of note in Science Immunology 2 (15)
This month’s articles highlight the adaptations in the maternal immune system during pregnancy and show how follicular regulatory T cells suppress B cell activation.
- Papers of note in Nature 549 (7673)
This week’s articles highlight the role of vitamin C in hematopoietic cells; a source of maternal inflammation that contributes to neurodevelopmental defects; the blocking of a niche factor that promotes the growth of gliomas; and a protein that influences DNA repair pathway choice.
About The Cover
Online Cover This week features a Research Article that describes how the EWS-FLI1 fusion protein inhibitor YK-4-279 synergizes with the chemotherapeutic vincristine to kill Ewing's sarcoma cells. The image shows immunofluorescent staining for the mitotic apparatus in Ewing's sarcoma cells treated with the combination. DNA, β-tubulin, and γ-tubulin are stained blue, green, and red, respectively. [Image: Zöllner et al., Science Signaling]