Editors' ChoiceCellular and Molecular Signaling

Papers of note in Nature 549 (7673)

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Science Signaling  03 Oct 2017:
Vol. 10, Issue 499, eaaq0229
DOI: 10.1126/scisignal.aaq0229

This week’s articles highlight the role of vitamin C in hematopoietic cells; a source of maternal inflammation that contributes to neurodevelopmental defects; the blocking of a niche factor that promotes the growth of gliomas; and a protein that influences DNA repair pathway choice.


Why vitamin C is good for hematopoietic cells

Agathocleous et al. found that ascorbate influences hematopoietic stem cell differentiation and leukemogenesis by binding to and modulating the activity of the tumor suppressor Tet2 (see also Miller and Ebert).

Fetal damage by maternal gut bacteria

Yim et al. and Kim et al. demonstrate that gut bacteria can initiate maternal inflammation that causes neurodevelopmental abnormalities in offspring (see also Powell).


Halting glioma growth

Venkatesh et al. reveal how neuroligin-3, a secreted synaptic adhesion molecule, promotes the growth of nearby gliomas and show that preventing its release from neighboring neurons blocks glioma growth (see also Taylor and Ramaswamy).


Suppressing error-prone repair

Arnoult et al. identify a protein that inhibits nonhomologous end joining during certain phases of the cell cycle, thus favoring homologous recombination, a less error-prone form of repair, during these phases.

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