Papers of note in Science Translational Medicine 9 (409)

Leslie K. Ferrarelli

doi:10.1126/scisignal.aaq0767

This week’s articles describe a stem cell–based therapy for chronic kidney disease and targets for treating diabetic nerve pain and acute respiratory distress in critically ill patients.

KIDNEY DISEASE

Cell therapy for renal anemia

Hitomi et al. report that transplantation of iPSC-derived cells that secrete functional erythropoietin may relieve anemia in patients with chronic kidney disease.

DIABETIC NEUROPATHY

Taking diabetic pain to heart

Tsantoulas et al. found that blocking HCN2 ion channels in peripheral sensory neurons reduces pain sensitivity in mouse models of diabetic neuropathy.

THROMBOSIS

Rip 'n’ roll

Yuan et al. show that inhibiting cell death pathways in platelets may limit neutrophil aggregation and prevent pulmonary thrombosis in patients with intestinal ischemia.

Highlighted Articles

1. H. Hitomi,
2. T. Kasahara,
3. N. Katagiri,
4. A. Hoshina,
5. S.-I. Mae,
6. M. Kotaka,
7. T. Toyohara,
8. A. Rahman,
9. D. Nakano,
10. A. Niwa,
11. M. K. Saito,
12. T. Nakahata,
13. A. Nishiyama,
14. K. Osafune
, Human pluripotent stem cell–derived erythropoietin-producing cells ameliorate renal anemia in mice. Sci. Transl. Med. 9, eaaj2300 (2017).
OpenUrl Abstract/FREE Full Text
1. C. Tsantoulas,
2. S. Laínez,
3. S. Wong,
4. I. Mehta,
5. B. Vilar,
6. P. A. McNaughton
, Hyperpolarization-activated cyclic nucleotide–gated 2 (HCN2) ion channels drive pain in mouse models of diabetic neuropathy. Sci. Transl. Med. 9, eaam6072 (2017).
OpenUrl
1. Y. Yuan,
2. I. Alwis,
3. M. C. L. Wu,
4. Z. Kaplan,
5. K. Ashworth,
6. D. Bark Jr.,
7. A. Pham,
8. J. Mcfadyen,
9. S. M. Schoenwaelder,
10. E. C. Josefsson,
11. B. T. Kile,
12. S. P. Jackson
, Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia. Sci. Transl. Med. 9, eaam5861 (2017).
OpenUrl Abstract/FREE Full Text

View Abstract

This week’s articles describe a stem cell–based therapy for chronic kidney disease and targets for treating diabetic nerve pain and acute respiratory distress in critically ill patients.

[1] H. Hitomi,
T. Kasahara,
N. Katagiri,
A. Hoshina,
S.-I. Mae,
M. Kotaka,
T. Toyohara,
A. Rahman,
D. Nakano,
A. Niwa,
M. K. Saito,
T. Nakahata,
A. Nishiyama,
K. Osafune
, Human pluripotent stem cell–derived erythropoietin-producing cells ameliorate renal anemia in mice. Sci. Transl. Med. 9, eaaj2300 (2017).
OpenUrl Abstract/FREE Full Text

[2] H. Hitomi,

[3] T. Kasahara,

[4] N. Katagiri,

[5] A. Hoshina,

[6] S.-I. Mae,

[7] M. Kotaka,

[8] T. Toyohara,

[9] A. Rahman,

[10] D. Nakano,

[11] A. Niwa,

[12] M. K. Saito,

[13] T. Nakahata,

[14] A. Nishiyama,

[15] K. Osafune

[16] C. Tsantoulas,
S. Laínez,
S. Wong,
I. Mehta,
B. Vilar,
P. A. McNaughton
, Hyperpolarization-activated cyclic nucleotide–gated 2 (HCN2) ion channels drive pain in mouse models of diabetic neuropathy. Sci. Transl. Med. 9, eaam6072 (2017).
OpenUrl

[17] C. Tsantoulas,

[18] S. Laínez,

[19] S. Wong,

[20] I. Mehta,

[21] B. Vilar,

[22] P. A. McNaughton

[23] Y. Yuan,
I. Alwis,
M. C. L. Wu,
Z. Kaplan,
K. Ashworth,
D. Bark Jr.,
A. Pham,
J. Mcfadyen,
S. M. Schoenwaelder,
E. C. Josefsson,
B. T. Kile,
S. P. Jackson
, Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia. Sci. Transl. Med. 9, eaam5861 (2017).
OpenUrl Abstract/FREE Full Text

[24] Y. Yuan,

[25] I. Alwis,

[26] M. C. L. Wu,

[27] Z. Kaplan,

[28] K. Ashworth,

[29] D. Bark Jr.,

[30] A. Pham,

[31] J. Mcfadyen,

[32] S. M. Schoenwaelder,

[33] E. C. Josefsson,

[34] B. T. Kile,

[35] S. P. Jackson

Papers of note in Science Translational Medicine 9 (409)

Highlighted Articles

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