Papers of note in Science Immunology 2  (15)

John F. Foley

doi:10.1126/scisignal.aaq0904

This month’s articles highlight the adaptations in the maternal immune system during pregnancy and show how follicular regulatory T cells suppress B cell activation.

SYSTEMS IMMUNOLOGY

Following the hand of the immunological clock

Aghaeepour et al. performed a systems-level analysis of the adaptations that occur in the maternal immune system during pregnancy.

IMMUNE REGULATION

Immune regulation in the germinal center

Ritvo et al. showed that follicular regulatory T cells suppress the activation of B cells by producing decoy molecules for an important signaling pathway.

Highlighted Articles

1. N. Aghaeepour,
2. E. A. Ganio,
3. D. Mcilwain,
4. A. S. Tsai,
5. M. Tingle,
6. S. Van Gassen,
7. D. K. Gaudilliere,
8. Q. Baca,
9. L. McNeil,
10. R. Okada,
11. M. S. Ghaemi,
12. D. Furman,
13. R. J. Wong,
14. V. D. Winn,
15. M. L. Druzin,
16. Y. Y. El-Sayed,
17. C. Quaintance,
18. R. Gibbs,
19. G. L. Darmstadt,
20. G. M. Shaw,
21. D. K. Stevenson,
22. R. Tibshirani,
23. G. P. Nolan,
24. D. B. Lewis,
25. M. S. Angst,
26. B. Gaudilliere
, An immune clock of human pregnancy. Sci. Immunol. 2, eaan2946 (2017).
OpenUrl Abstract/FREE Full Text
1. P.-G. G. Ritvo,
2. G. Churlaud,
3. V. Quiniou,
4. L. Florez,
5. F. Brimaud,
6. G. Fourcade,
7. E. Mariotti-Ferrandiz,
8. D. Klatzmann
, T_fr cells lack IL-2Rα but express decoy IL-1R2 and IL-1Ra and suppress the IL-1–dependent activation of T_fh cells. Sci. Immunol. 2, eaan0368 (2017).
OpenUrl Abstract/FREE Full Text

View Abstract

This month’s articles highlight the adaptations in the maternal immune system during pregnancy and show how follicular regulatory T cells suppress B cell activation.

[1] N. Aghaeepour,
E. A. Ganio,
D. Mcilwain,
A. S. Tsai,
M. Tingle,
S. Van Gassen,
D. K. Gaudilliere,
Q. Baca,
L. McNeil,
R. Okada,
M. S. Ghaemi,
D. Furman,
R. J. Wong,
V. D. Winn,
M. L. Druzin,
Y. Y. El-Sayed,
C. Quaintance,
R. Gibbs,
G. L. Darmstadt,
G. M. Shaw,
D. K. Stevenson,
R. Tibshirani,
G. P. Nolan,
D. B. Lewis,
M. S. Angst,
B. Gaudilliere
, An immune clock of human pregnancy. Sci. Immunol. 2, eaan2946 (2017).
OpenUrl Abstract/FREE Full Text

[2] N. Aghaeepour,

[3] E. A. Ganio,

[4] D. Mcilwain,

[5] A. S. Tsai,

[6] M. Tingle,

[7] S. Van Gassen,

[8] D. K. Gaudilliere,

[9] Q. Baca,

[10] L. McNeil,

[11] R. Okada,

[12] M. S. Ghaemi,

[13] D. Furman,

[14] R. J. Wong,

[15] V. D. Winn,

[16] M. L. Druzin,

[17] Y. Y. El-Sayed,

[18] C. Quaintance,

[19] R. Gibbs,

[20] G. L. Darmstadt,

[21] G. M. Shaw,

[22] D. K. Stevenson,

[23] R. Tibshirani,

[24] G. P. Nolan,

[25] D. B. Lewis,

[26] M. S. Angst,

[27] B. Gaudilliere

[28] P.-G. G. Ritvo,
G. Churlaud,
V. Quiniou,
L. Florez,
F. Brimaud,
G. Fourcade,
E. Mariotti-Ferrandiz,
D. Klatzmann
, T_fr cells lack IL-2Rα but express decoy IL-1R2 and IL-1Ra and suppress the IL-1–dependent activation of T_fh cells. Sci. Immunol. 2, eaan0368 (2017).
OpenUrl Abstract/FREE Full Text

[29] P.-G. G. Ritvo,

[30] G. Churlaud,

[31] V. Quiniou,

[32] L. Florez,

[33] F. Brimaud,

[34] G. Fourcade,

[35] E. Mariotti-Ferrandiz,

[36] D. Klatzmann

Papers of note in Science Immunology 2 (15)

Highlighted Articles

Science Signaling

Article Tools