Contents
10 October 2017
Vol 10, Issue 500
Vol 10, Issue 500
Research Articles
- Temperature-activated ion channels in neural crest cells confer maternal fever–associated birth defects
Fever during the first trimester may induce birth defects by activating TRPV ion channels in neural crest cells.
- Dual enhancement of T and NK cell function by pulsatile inhibition of SHIP1 improves antitumor immunity and survival
Intermittent inhibition of the phosphatase SHIP1 promotes antitumor immunity and memory in mouse models of lymphoma and colon cancer.
- Foxo1 and Foxp1 play opposing roles in regulating the differentiation and antitumor activity of TH9 cells programmed by IL-7
The cytokine IL-7 enhances the generation and antitumor activity of a T cell subset that may be used in cancer immunotherapy.
Editors' Choice
- New connections: Pregnancy-specific signaling
Three papers highlight the cross-talk that occurs between mother and fetus during pregnancy.
- Highlight: Antitumor strategies
Two papers highlight potential ways to boost the antitumor immune response.
- Papers of note in Science Translational Medicine 9 (410)
This week’s article and a review describe ways to potentially improve immunotherapy for cancer patients.
- Papers of note in Nature 550 (7674)
This week’s articles highlight retrograde semaphorin signaling at synapses; a driver of age-related decreases in lipolysis; and a mechanism by which melanoma cells become resistant to combined therapies.
About The Cover
Online Cover This week features a Research Article that shows that birth defects associated with maternal fevers during the first trimester may arise from activation of the ion channels TRPV1 and TRPV4 in neural crest cells. The image shows the cranial features of a chick, one of the model organisms used by the authors. [Image: Hutson et al./Science Signaling]