Editors' ChoiceCellular and Molecular Signaling

Papers of note in Nature 550 (7674)

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Science Signaling  10 Oct 2017:
Vol. 10, Issue 500, eaaq1217
DOI: 10.1126/scisignal.aaq1217

This week’s articles highlight retrograde semaphorin signaling at synapses; a driver of age-related decreases in lipolysis; and a mechanism by which melanoma cells become resistant to combined therapies.


Retrograde semaphorin signaling at synapses

Orr et al. report that signaling from postsynaptic semaphorin to presynaptic plexin contributes to hemeostatic plasticity in Drosophila by controlling the readily releasable pool of synaptic vesicles.


Why lipolysis declines with age

Camell et al. describe an inflammasome-dependent mechanism by which adipose tissue macrophages contribute to the age-related decline of lipolysis in adipocytes.


Acquired resistance to combined therapies

Lu et al. identified mechanisms by which p21-activated kinases (PAKs) mediate resistance to combined therapies in BRAF-driven melanoma.

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