Contents
17 October 2017
Vol 10, Issue 501
Vol 10, Issue 501
Research Articles
- Resveratrol stimulates the metabolic reprogramming of human CD4+ T cells to enhance effector function
Resveratrol alters human T cell responsiveness to antigens, coupling a replication stress response to metabolic reprogramming.
- The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1
Endothelial cell senescence induced by TSP1 and its receptor CD47 is mediated by Nox1-dependent oxidative stress.
- Olfactory experience primes the heat shock transcription factor HSF-1 to enhance the expression of molecular chaperones in C. elegans
The odor of a pathogenic bacterium primes nematodes to respond to the pathogen when they eventually encounter it.
Editors' Choice
- Tuning insulin sensitivity by exosome
Adipose tissue macrophages release exosomes containing microRNAs that modulate insulin sensitivity.
- Papers of note in Science 358 (6360)
This week’s articles identify distinct mechanisms of apoptosis in different areas of the germinal center and present an interactive virtual fly embryo that shows the expression of signaling pathway components and other regulatory molecules in individual cells.
- Papers of note in Science Translational Medicine 9 (411)
This week’s articles describe ways to potentially prevent heart failure after myocardial infarction and treat the autoimmune disease plaque psoriasis.
- Papers of note in Nature 550 (7675)
The articles highlighted this week focus on signaling events that control appetite and weight; the effects of Hippo signaling on cell function during cardiac repair; a mechanism that drives cancer drug addiction; inactivation of a kinase complex by structural rearrangement; and the mechanism by which a noncoding viral RNA inhibits host cell apoptosis.
About The Cover
Online Cover This week features a Research Article that examined the effect of resveratrol, a polyphenolic compound found in grapes, on human CD4+ T cell function. When used at low doses, resveratrol reprogrammed the metabolism of the T cells, making them more responsive to antigen and enhancing their production of an inflammatory cytokine, suggesting that the therapeutic use of resveratrol should be carefully assessed. [Image: AlekseyMorozov/shutterstock]