Research ArticleAging

The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1

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Science Signaling  17 Oct 2017:
Vol. 10, Issue 501, eaaj1784
DOI: 10.1126/scisignal.aaj1784

Keeping endothelial cells young

Aging causes once-proliferating cells to undergo cell cycle arrest and become senescent, thus impairing tissue and organ function. Meijles et al. delineated a pathway that induced senescence in mouse and human endothelial cells. Binding of the matricellular protein TSP1 to its receptor CD47 activated the enzyme Nox1, which generates reactive oxygen species. The subsequent oxidative stress triggered a p53-dependent DNA damage response pathway that resulted in cell cycle arrest. These results suggest that targeting TSP1, CD47, or Nox1 could delay or reverse cellular senescence in the endothelium, which could help improve the quality of life for the growing aging population.

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