The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1

Daniel N. Meijles; Sanghamitra Sahoo; Imad Al Ghouleh; Jefferson H. Amaral; Raquel Bienes-Martinez; Heather E. Knupp; Shireen Attaran; John C. Sembrat; Seyed M. Nouraie; Mauricio M. Rojas; Enrico M. Novelli; Mark T. Gladwin; Jeffrey S. Isenberg; Eugenia Cifuentes-Pagano; Patrick J. Pagano

doi:10.1126/scisignal.aaj1784

Research ArticleAging

The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1

View ORCID ProfileDaniel N. Meijles¹,²,*,
Sanghamitra Sahoo¹,²,
View ORCID ProfileImad Al Ghouleh¹,²,³,
View ORCID ProfileJefferson H. Amaral¹,²,
View ORCID ProfileRaquel Bienes-Martinez¹,
View ORCID ProfileHeather E. Knupp¹,
Shireen Attaran²,
View ORCID ProfileJohn C. Sembrat¹,²,
View ORCID ProfileSeyed M. Nouraie⁴,
Mauricio M. Rojas¹,⁴,
Enrico M. Novelli¹,
Mark T. Gladwin¹,⁴,
Jeffrey S. Isenberg¹,²,⁴,
Eugenia Cifuentes-Pagano¹,², and
View ORCID ProfilePatrick J. Pagano¹,²,†

¹Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.
²Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
³Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
⁴Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.

↵†Corresponding author. Email: pagano{at}pitt.edu

↵* Present address: Molecular and Clinical Sciences Research Institute, St. George’s University of London, London SW17 0RE, UK.

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Science Signaling 17 Oct 2017:
Vol. 10, Issue 501, eaaj1784
DOI: 10.1126/scisignal.aaj1784

Daniel N. Meijles

1Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.

2Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA.

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ORCID record for Daniel N. Meijles

Sanghamitra Sahoo

1Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.

2Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA.

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Imad Al Ghouleh

1Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.

2Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA.

3Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.

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Jefferson H. Amaral

1Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.

2Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA.

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Raquel Bienes-Martinez

1Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.

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Heather E. Knupp

1Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.

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Shireen Attaran

2Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA.

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John C. Sembrat

1Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.

2Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA.

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Seyed M. Nouraie

4Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.

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ORCID record for Seyed M. Nouraie

Mauricio M. Rojas

1Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.

4Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.

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Enrico M. Novelli

1Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.

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Mark T. Gladwin

1Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.

4Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.

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Jeffrey S. Isenberg

1Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.

2Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA.

4Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.

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Eugenia Cifuentes-Pagano

1Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.

2Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA.

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Patrick J. Pagano

1Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.

2Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA.

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For correspondence: pagano@pitt.edu

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The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1

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