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Resveratrol stimulates the metabolic reprogramming of human CD4+ T cells to enhance effector function

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Science Signaling  17 Oct 2017:
Vol. 10, Issue 501, eaal3024
DOI: 10.1126/scisignal.aal3024

Resveratrol and lymphocyte responses

Resveratrol is a polyphenolic plant compound, which has attracted much interest as a pharmacological agent because of its potential therapeutic effects against cancer, aging, and inflammation. However, many studies have produced conflicting evidence of the effects of resveratrol in different contexts. Craveiro et al. found that high doses of resveratrol inhibited the responses of human CD4+ T cells to antigens. However, low doses of the drug reprogrammed the metabolism of the cells to make them more responsive to antigens and produce increased amounts of the inflammatory cytokine interferon-γ. These data suggest that the use of resveratrol to treat various pathologies should be carefully assessed, especially in an autoimmune setting.

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