Papers of note in Science Translational Medicine 9 (411)

Leslie K. Ferrarelli

doi:10.1126/scisignal.aar2006

This week’s articles describe ways to potentially prevent heart failure after myocardial infarction and treat the autoimmune disease plaque psoriasis.

CARDIOVASCULAR DISEASE

Lipoprotein lends a hand for heart attacks

Heywood et al. report that in both healthy and insulin-resistant mice, administration of high-density lipoprotein after a heart attack increases cardiac glucose uptake and function through activation of AKT signaling.

AUTOIMMUNE DISEASE

Nixing IL-36 in psoriasis

Mahil et al. show that the cytokine IL-36 mediates the inflammation associated with plaque psoriasis.

Highlighted Articles

1. S. E. Heywood,
2. A. L. Richart,
3. D. C. Henstridge,
4. K. Alt,
5. H. Kiriazis,
6. C. Zammit,
7. A. L. Carey,
8. H. L. Kammoun,
9. L. M. Delbridge,
10. M. Reddy,
11. Y.-C. Chen,
12. X.-J. Du,
13. C. E. Hagemeyer,
14. M. A. Febbraio,
15. A. L. Siebel,
16. B. A. Kingwell
, High-density lipoprotein delivered after myocardial infarction increases cardiac glucose uptake and function in mice. Sci. Transl. Med. 9, eaam6084 (2017).
OpenUrl Abstract/FREE Full Text
1. S. K. Mahil,
2. M. Catapano,
3. P. Di Meglio,
4. N. Dand,
5. H. Ahlfors,
6. I. M. Carr,
7. C. H. Smith,
8. R. C. Trembath,
9. M. Peakman,
10. J. Wright,
11. F. D. Ciccarelli,
12. J. N. Barker,
13. F. Capon
, An analysis of IL-36 signature genes and individuals with IL1RL2 knockout mutations validates IL-36 as a psoriasis therapeutic target. Sci. Transl. Med. 9, eaan2514 (2017).
OpenUrl Abstract/FREE Full Text

View Abstract

This week’s articles describe ways to potentially prevent heart failure after myocardial infarction and treat the autoimmune disease plaque psoriasis.

[1] S. E. Heywood,
A. L. Richart,
D. C. Henstridge,
K. Alt,
H. Kiriazis,
C. Zammit,
A. L. Carey,
H. L. Kammoun,
L. M. Delbridge,
M. Reddy,
Y.-C. Chen,
X.-J. Du,
C. E. Hagemeyer,
M. A. Febbraio,
A. L. Siebel,
B. A. Kingwell
, High-density lipoprotein delivered after myocardial infarction increases cardiac glucose uptake and function in mice. Sci. Transl. Med. 9, eaam6084 (2017).
OpenUrl Abstract/FREE Full Text

[2] S. E. Heywood,

[3] A. L. Richart,

[4] D. C. Henstridge,

[5] K. Alt,

[6] H. Kiriazis,

[7] C. Zammit,

[8] A. L. Carey,

[9] H. L. Kammoun,

[10] L. M. Delbridge,

[11] M. Reddy,

[12] Y.-C. Chen,

[13] X.-J. Du,

[14] C. E. Hagemeyer,

[15] M. A. Febbraio,

[16] A. L. Siebel,

[17] B. A. Kingwell

[18] S. K. Mahil,
M. Catapano,
P. Di Meglio,
N. Dand,
H. Ahlfors,
I. M. Carr,
C. H. Smith,
R. C. Trembath,
M. Peakman,
J. Wright,
F. D. Ciccarelli,
J. N. Barker,
F. Capon
, An analysis of IL-36 signature genes and individuals with IL1RL2 knockout mutations validates IL-36 as a psoriasis therapeutic target. Sci. Transl. Med. 9, eaan2514 (2017).
OpenUrl Abstract/FREE Full Text

[19] S. K. Mahil,

[20] M. Catapano,

[21] P. Di Meglio,

[22] N. Dand,

[23] H. Ahlfors,

[24] I. M. Carr,

[25] C. H. Smith,

[26] R. C. Trembath,

[27] M. Peakman,

[28] J. Wright,

[29] F. D. Ciccarelli,

[30] J. N. Barker,

[31] F. Capon

Papers of note in Science Translational Medicine 9 (411)

Highlighted Articles

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