Contents
24 October 2017
Vol 10, Issue 502
Vol 10, Issue 502
Research Articles
- The scaffolding protein Cnk binds to the receptor tyrosine kinase Alk to promote visceral founder cell specification in Drosophila
Alk signaling in the developing Drosophila visceral mesoderm requires the scaffolding protein Cnk and its binding partner Ave.
- TGF-β receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis
Ceramide forms complexes with Smad7 to inhibit cell migration–associated TGF-β–sonic hedgehog signaling in primary cilia.
- TCR-stimulated changes in cell surface CD46 expression generate type 1 regulatory T cells
Defects in the T cell receptor–stimulated processing of a cell surface receptor may contribute to the pathogenesis of autoimmune diseases.
Editors' Choice
- A supersuppressor for pancreatic cancer
A mutation in p53 enhances its induction of a phosphatase that inhibits YAP, a critical mediator of pancreatic cancer development.
- Papers of note in Science 358 (6361)
This week’s articles highlight the role of adrenergic nerves in cancer growth; natural polyreactive antibodies that recognize gut microbiota; and structural insights into mTORC1 and D4 dopamine receptor signaling.
- Papers of note in Science Translational Medicine 9 (412)
This week’s articles describe ways to potentially treat obesity-associated disorders and prevent sepsis.
- Papers of note in Nature 550 (7676)
This week’s articles identify a mechanism that establishes the senescence-associated secretory phenotype and reveal details about the gating of TRPML channels.
About The Cover
Online Cover This week features a Research Article that identifies the scaffolding protein Cnk and its binding partner Ave as critical components downstream of the receptor tyrosine kinase Alk and its ligand Jeb in the developing Drosophila visceral mesoderm. The image shows the lack of visceral myotubes in embryos overexpressing Cnk (middle and bottom) compared to control embryos (top). [Image: Wolfstetter et al./Science Signaling]