This week’s articles highlight the role of adrenergic nerves in cancer growth; natural polyreactive antibodies that recognize gut microbiota; and structural insights into mTORC1 and D4 dopamine receptor signaling.
CANCER
Tumor angiogenesis gets nervous
Zahalka et al. found that neural signals promote prostate cancer growth by altering endothelial cell metabolism and inducing tumor angiogenesis (see the Perspective by Hayakawa and Wang).
HOST-MICROBE INTERACTIONS
Programmed recognition of microbiota
Bunker et al. identified inherently polyreactive antibodies that fuel homeostatic intestinal immunoglobulin A responses to the normal gut microbiota.
STRUCTURAL BIOLOGY
Structure of human mTORC1 components
De Araujo et al. report structural insights into nutrient and growth factor signaling at the lysosome.
A strategy for drug discovery
Wang et al. present high-resolution D4 dopamine receptor crystal structures that facilitate the discovery of new ligands.
