This week’s articles identify a mechanism that establishes the senescence-associated secretory phenotype and reveal details about the gating of TRPML channels.
CELL BIOLOGY
Inflammation in senescent cells
Dou et al. demonstrate that the presence of chromatin in the cytoplasm of senescent cells triggers inflammation and establishes the senescence-associated secretory phenotype (see also Umbreit and Pellman).
STRUCTURAL BIOLOGY
TRPML structures
Three new structural studies by Schmiege et al., Hirschi et al., and Chen et al. elucidate the gating mechanism of transient receptor potential mucolipin (TRPML) cation channels.