Papers of note in Nature 550 (7676)

Annalisa M. VanHook

doi:10.1126/scisignal.aar2567

This week’s articles identify a mechanism that establishes the senescence-associated secretory phenotype and reveal details about the gating of TRPML channels.

CELL BIOLOGY

Inflammation in senescent cells

Dou et al. demonstrate that the presence of chromatin in the cytoplasm of senescent cells triggers inflammation and establishes the senescence-associated secretory phenotype (see also Umbreit and Pellman).

STRUCTURAL BIOLOGY

TRPML structures

Three new structural studies by Schmiege et al., Hirschi et al., and Chen et al. elucidate the gating mechanism of transient receptor potential mucolipin (TRPML) cation channels.

Highlighted Articles

1. Z. Dou,
2. K. Ghosh,
3. M. G. Vizioli,
4. J. Zhu,
5. P. Sen,
6. K. J. Wangensteen,
7. J. Simithy,
8. Y. Lan,
9. Y. Lin,
10. Z. Zhou,
11. B. C. Capell,
12. C. Xu,
13. M. Xu,
14. J. E. Kieckhaefer,
15. T. Jiang,
16. M. Shoshkes-Carmel,
17. K. M. A. A. Tanim,
18. G. N. Barber,
19. J. T. Seykora,
20. S. E. Millar,
21. K. H. Kaestner,
22. B. A. Garcia,
23. P. D. Adams,
24. S. L. Berger
, Cytoplasmic chromatin triggers inflammation in senescence and cancer. Nature 550, 402–406 (2017).
OpenUrl
1. N. T. Umbreit,
2. D. Pellman
, Genome jail-break triggers lockdown. Nature 550, 340–341 (2017).
OpenUrl
1. P. Schmiege,
2. M. Fine,
3. G. Blobel,
4. X. Li
, Human TRPML1 channel structures in open and closed conformations. Nature 550, 366–370 (2017).
OpenUrl
1. M. Hirschi,
2. M. A. Herzik Jr.,
3. J. Wie,
4. Y. Suo,
5. W. F. Borschel,
6. D. Ren,
7. G. C. Lander,
8. S.-Y. Lee
, Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3. Nature 550, 411–414 (2017).
OpenUrl
1. Q. Chen,
2. J. She,
3. W. Zeng,
4. J. Guo,
5. H. Xu,
6. X.-c. Bai,
7. Y. Jiang
, Structure of mammalian endolysosomal TRPML1 channel in nanodiscs. Nature 550, 415–418 (2017).
OpenUrl

This week’s articles identify a mechanism that establishes the senescence-associated secretory phenotype and reveal details about the gating of TRPML channels.

[1] Z. Dou,
K. Ghosh,
M. G. Vizioli,
J. Zhu,
P. Sen,
K. J. Wangensteen,
J. Simithy,
Y. Lan,
Y. Lin,
Z. Zhou,
B. C. Capell,
C. Xu,
M. Xu,
J. E. Kieckhaefer,
T. Jiang,
M. Shoshkes-Carmel,
K. M. A. A. Tanim,
G. N. Barber,
J. T. Seykora,
S. E. Millar,
K. H. Kaestner,
B. A. Garcia,
P. D. Adams,
S. L. Berger
, Cytoplasmic chromatin triggers inflammation in senescence and cancer. Nature 550, 402–406 (2017).
OpenUrl

[2] Z. Dou,

[3] K. Ghosh,

[4] M. G. Vizioli,

[5] J. Zhu,

[6] P. Sen,

[7] K. J. Wangensteen,

[8] J. Simithy,

[9] Y. Lan,

[10] Y. Lin,

[11] Z. Zhou,

[12] B. C. Capell,

[13] C. Xu,

[14] M. Xu,

[15] J. E. Kieckhaefer,

[16] T. Jiang,

[17] M. Shoshkes-Carmel,

[18] K. M. A. A. Tanim,

[19] G. N. Barber,

[20] J. T. Seykora,

[21] S. E. Millar,

[22] K. H. Kaestner,

[23] B. A. Garcia,

[24] P. D. Adams,

[25] S. L. Berger

[26] N. T. Umbreit,
D. Pellman
, Genome jail-break triggers lockdown. Nature 550, 340–341 (2017).
OpenUrl

[27] N. T. Umbreit,

[28] D. Pellman

[29] P. Schmiege,
M. Fine,
G. Blobel,
X. Li
, Human TRPML1 channel structures in open and closed conformations. Nature 550, 366–370 (2017).
OpenUrl

[30] P. Schmiege,

[31] M. Fine,

[32] G. Blobel,

[33] X. Li

[34] M. Hirschi,
M. A. Herzik Jr.,
J. Wie,
Y. Suo,
W. F. Borschel,
D. Ren,
G. C. Lander,
S.-Y. Lee
, Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3. Nature 550, 411–414 (2017).
OpenUrl

[35] M. Hirschi,

[36] M. A. Herzik Jr.,

[37] J. Wie,

[38] Y. Suo,

[39] W. F. Borschel,

[40] D. Ren,

[41] G. C. Lander,

[42] S.-Y. Lee

[43] Q. Chen,
J. She,
W. Zeng,
J. Guo,
H. Xu,
X.-c. Bai,
Y. Jiang
, Structure of mammalian endolysosomal TRPML1 channel in nanodiscs. Nature 550, 415–418 (2017).
OpenUrl

[44] Q. Chen,

[45] J. She,

[46] W. Zeng,

[47] J. Guo,

[48] H. Xu,

[49] X.-c. Bai,

[50] Y. Jiang

Papers of note in Nature 550 (7676)

Highlighted Articles

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