Research ResourceTechniques Quantitative single-molecule imaging of TLR4 reveals ligand-specific receptor dimerization View ORCID ProfileCarmen L. Krüger1, View ORCID ProfileMarie-Theres Zeuner2, View ORCID ProfileGraeme S. Cottrell3, Darius Widera2, and View ORCID ProfileMike Heilemann1,*1Institute of Physical and Theoretical Chemistry, Goethe University, Max von Laue Straße 7, 60438 Frankfurt/Main, Germany.2Stem Cell Biology and Regenerative Medicine, School of Pharmacy, University of Reading, Hopkins Building, Whiteknights, Reading RG6 6UB, UK.3Cellular and Molecular Neuroscience, School of Pharmacy, University of Reading, Hopkins Building, Whiteknights, Reading RG6 6UB, UK.↵*Corresponding author. Email: heilemann{at}chemie.uni-frankfurt.de See allHide authors and affiliations Science Signaling 31 Oct 2017:Vol. 10, Issue 503, eaan1308DOI: 10.1126/scisignal.aan1308 Carmen L. Krüger 1Institute of Physical and Theoretical Chemistry, Goethe University, Max von Laue Straße 7, 60438 Frankfurt/Main, Germany.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Carmen L. Krüger Marie-Theres Zeuner 2Stem Cell Biology and Regenerative Medicine, School of Pharmacy, University of Reading, Hopkins Building, Whiteknights, Reading RG6 6UB, UK.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Marie-Theres Zeuner Graeme S. Cottrell 3Cellular and Molecular Neuroscience, School of Pharmacy, University of Reading, Hopkins Building, Whiteknights, Reading RG6 6UB, UK.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Graeme S. Cottrell Darius Widera 2Stem Cell Biology and Regenerative Medicine, School of Pharmacy, University of Reading, Hopkins Building, Whiteknights, Reading RG6 6UB, UK.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Mike Heilemann 1Institute of Physical and Theoretical Chemistry, Goethe University, Max von Laue Straße 7, 60438 Frankfurt/Main, Germany.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Mike Heilemann For correspondence: heilemann@chemie.uni-frankfurt.de Article Figures & Data Info & Metrics eLetters PDF Article Information vol. 10 no. 503 DOI: https://doi.org/10.1126/scisignal.aan1308 PubMed: 29089449 Published By: Science Signaling Print ISSN: 1945-0877 Online ISSN: 1937-9145 History: Received March 8, 2017Accepted October 13, 2017 . Copyright & Usage: Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works http://www.sciencemag.org/about/science-licenses-journal-article-reuseThis is an article distributed under the terms of the Science Journals Default License. Author Information Altmetric Article usage Article lifetimeLast 6 monthsThis monthArticle usage: October 2017 to January 2021 AbstractFullPdf Oct 20179796595 Nov 20175622256390 Dec 20172122739 Jan 20181882238 Feb 20181521926 Mar 20181963742 Apr 20181312117 May 20181253120 Jun 20181083617 Jul 2018802823 Aug 20181074714 Sep 201877325 Oct 2018985023 Nov 2018014334 Dec 2018010526 Jan 2019111437 Feb 2019412431 Mar 2019312844 Apr 201936930 May 2019108927 Jun 201986927 Jul 201987533 Aug 201976636 Sep 201977136 Oct 201997526 Nov 2019106936 Dec 2019119331 Jan 2020412151 Feb 202036048 Mar 202057473 Apr 2020210251 May 202016826 Jun 202055822 Jul 202077240 Aug 202035514 Sep 202045817 Oct 202088838 Nov 202086121 Dec 202036125 Jan 2021116135 View Full Text
Quantitative single-molecule imaging of TLR4 reveals ligand-specific receptor dimerization By Carmen L. Krüger, Marie-Theres Zeuner, Graeme S. Cottrell, Darius Widera, Mike Heilemann Science Signaling31 Oct 2017 Superresolution imaging of the pattern recognition receptor TLR4 reveals how different ligands control receptor dimerization.
Quantitative single-molecule imaging of TLR4 reveals ligand-specific receptor dimerization By Carmen L. Krüger, Marie-Theres Zeuner, Graeme S. Cottrell, Darius Widera, Mike Heilemann Science Signaling31 Oct 2017 Superresolution imaging of the pattern recognition receptor TLR4 reveals how different ligands control receptor dimerization.