This week’s articles highlight inflammatory memory in epithelial stem cells; ubiquitin-specific protease inhibitors that target cancer cells; the identification of a sphingosine 1-phosphate exporter; and G protein signaling hotspots on the plasma membrane.
INFLAMMATION
Memories of inflammation
Naik et al. report that epithelial stem cells’ ability to “remember” past inflammation depends on the activity of the AIM2 inflammasome (see also Dai and Medzhitov).
CANCER
USP inhibitors induce tumor cell death
Turnbull et al. and Kategaya et al. developed small-molecule inhibitors of the ubiquitin-specific protease USP7 that inhibit tumor growth in mice.
CELL BIOLOGY
S1P exporter identified
Vu et al. show that the transmembrane protein Mfsd2b mediates the release of sphingosine-1-phosphate from platelets and red blood cells.
G protein signaling hot spots
Sungkaworn et al. used single-molecule imaging to demonstrate that G protein–coupled receptors interact with G proteins in defined cell surface domains.