Contents
07 November 2017
Vol 10, Issue 504
Vol 10, Issue 504
Research Articles
- Aberrant Rac1-cofilin signaling mediates defects in dendritic spines, synaptic function, and sensory perception in fragile X syndrome
Inhibiting Rac1-PAK-LIMK signaling may restore synaptic function and sensory processing in patients with fragile X syndrome.
- Reducing eIF4E-eIF4G interactions restores the balance between protein synthesis and actin dynamics in fragile X syndrome model mice
Inhibiting the translation initiation factor eIF4E corrects neuronal behavioral phenotypes in a mouse model of fragile X syndrome.
- Neuronal activity drives FMRP- and HSPG-dependent matrix metalloproteinase function required for rapid synaptogenesis
The secreted protease MMP1 is localized by a cell surface proteoglycan to mediate activity-induced synaptogenesis.
Editors' Choice
- Special issue: Fragile X syndrome
In this issue of Science Signaling, three papers uncover molecular mechanisms of neurological dysfunction in animal models of fragile X syndrome.
- Papers of note in Science 358 (6363)
This week’s articles describe the identification of a mammalian protein that is required for endoplasmic reticulum–mitochondria tethering and regulates intracellular calcium dynamics in neurons.
- Papers of note in Science Translational Medicine 9 (414)
This week’s articles describe new ways to treat some types of GI cancer and various childhood solid tumors.
- Papers of note in Nature 551 (7678)
This week’s papers address the involvement of TGF-β signaling in the differentiation of TH17 cells, a checkpoint that restrains the antitumor and antivirus activities of natural killer cells, and a mechanism for erasing a parental epigenetic memory in plant embryos.
About The Cover
Online Cover This week features a Special Issue of three Research Articles that uncover molecular mechanisms and potential therapeutic targets in animal models of fragile X syndrome. The image shows an artist's rendition of the fragile X chromosome in the foreground of a network of dendritic spines. [Image: A. Kitterman/Science Signaling]