Research ArticleFRAGILE X SYNDROME Neuronal activity drives FMRP- and HSPG-dependent matrix metalloproteinase function required for rapid synaptogenesis View ORCID ProfileMary L. Dear1,*, View ORCID ProfileJarrod Shilts1,†, and View ORCID ProfileKendal Broadie1,2,3,*,‡1Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA.2Department of Cell and Developmental Biology, Vanderbilt University and Medical School, Nashville, TN 37232, USA.3Vanderbilt Brain Institute, Vanderbilt University and Medical School, Nashville, TN 37232, USA.↵‡Corresponding author. Email: kendal.broadie{at}vanderbilt.edu↵* Present address: 6270A Medical Research Building III, Vanderbilt University, 465 21st Avenue South, Nashville, TN 37232, USA.↵† Present address: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK. See allHide authors and affiliations Science Signaling 07 Nov 2017:Vol. 10, Issue 504, eaan3181DOI: 10.1126/scisignal.aan3181 Mary L. Dear 1Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Mary L. Dear Jarrod Shilts 1Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Jarrod Shilts Kendal Broadie 1Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA.2Department of Cell and Developmental Biology, Vanderbilt University and Medical School, Nashville, TN 37232, USA.3Vanderbilt Brain Institute, Vanderbilt University and Medical School, Nashville, TN 37232, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Kendal Broadie For correspondence: kendal.broadie@vanderbilt.edu Article Figures & Data Info & Metrics eLetters PDF Article Information vol. 10 no. 504 DOI: https://doi.org/10.1126/scisignal.aan3181 PubMed: 29114039 Published By: Science Signaling Print ISSN: 1945-0877 Online ISSN: 1937-9145 History: Received March 30, 2017Accepted October 13, 2017 . Copyright & Usage: Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works http://www.sciencemag.org/about/science-licenses-journal-article-reuseThis is an article distributed under the terms of the Science Journals Default License. Author Information Altmetric Article usage Article lifetimeLast 6 monthsThis monthArticle usage: November 2017 to February 2021 AbstractFullPdf Nov 2017315177196 Dec 2017186789 Jan 20181251621 Feb 201895811 Mar 2018761319 Apr 2018741616 May 201898107 Jun 20184275 Jul 2018651615 Aug 201852111 Sep 201821124 Oct 2018311912 Nov 2018724912 Dec 2018028616 Jan 2019223317 Feb 2019118612 Mar 20193858 Apr 201903018 May 201923517 Jun 20190218 Jul 20190219 Aug 201902912 Sep 201932011 Oct 20192329 Nov 201952515 Dec 201933011 Jan 202002816 Feb 20202257 Mar 202031916 Apr 202021712 May 202003336 Jun 202034520 Jul 202044613 Aug 20201206 Sep 202052910 Oct 202036217 Nov 20203277 Dec 202032626 Jan 202132224 Feb 20210326 View Full Text
Neuronal activity drives FMRP- and HSPG-dependent matrix metalloproteinase function required for rapid synaptogenesis By Mary L. Dear, Jarrod Shilts, Kendal Broadie Science Signaling07 Nov 2017 The secreted protease MMP1 is localized by a cell surface proteoglycan to mediate activity-induced synaptogenesis. Supplementary Materials
Neuronal activity drives FMRP- and HSPG-dependent matrix metalloproteinase function required for rapid synaptogenesis By Mary L. Dear, Jarrod Shilts, Kendal Broadie Science Signaling07 Nov 2017 The secreted protease MMP1 is localized by a cell surface proteoglycan to mediate activity-induced synaptogenesis. Supplementary Materials