Papers of note in Science Translational Medicine 9 (414)

Leslie K. Ferrarelli

doi:10.1126/scisignal.aar3827

This week’s articles describe new ways to treat some types of GI cancer and various childhood solid tumors.

CANCER

A targeted KIT inhibitor

Evans et al. show that an active-conformation inhibitor of the kinases KIT and PDGFRA is effective in patients with gastrointestinal cancer.

An Achilles’ heel in childhood cancers

Henssen et al. show that inhibiting nonhomologous end joining–mediated repair of DNA may kill various childhood-associated solid tumors that express the DNA transposase PGBD5.

Highlighted Articles

1. E. K. Evans,
2. A. K. Gardino,
3. J. L. Kim,
4. B. L. Hodous,
5. A. Shutes,
6. A. Davis,
7. X. J. Zhu,
8. O. Schmidt-Kittler,
9. D. Wilson,
10. K. Wilson,
11. L. DiPietro,
12. Y. Zhang,
13. N. Brooijmans,
14. T. P. LaBranche,
15. A. Wozniak,
16. Y. K. Gebreyohannes,
17. P. Schöffski,
18. M. C. Heinrich,
19. D. J. DeAngelo,
20. S. Miller,
21. B. Wolf,
22. N. Kohl,
23. T. Guzi,
24. N. Lydon,
25. A. Boral,
26. C. Lengauer
, A precision therapy against cancers driven by KIT/PDGFRA mutations. Sci. Transl. Med. 9, eaao1690 (2017).
OpenUrl Abstract/FREE Full Text
1. A. G. Henssen,
2. C. Reed,
3. E. Jiang,
4. H. D. Garcia,
5. J. von Stebut,
6. I. C. MacArthur,
7. P. Hundsdoerfer,
8. J. H. Kim,
9. E. de Stanchina,
10. Y. Kuwahara,
11. H. Hosoi,
12. N. J. Ganem,
13. F. Dela Cruz,
14. A. L. Kung,
15. J. H. Schulte,
16. J. H. Petrini,
17. A. Kentsis
, Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors. Sci. Transl. Med. 9, eaam9078 (2017).
OpenUrl Abstract/FREE Full Text

View Abstract

[1] E. K. Evans,
A. K. Gardino,
J. L. Kim,
B. L. Hodous,
A. Shutes,
A. Davis,
X. J. Zhu,
O. Schmidt-Kittler,
D. Wilson,
K. Wilson,
L. DiPietro,
Y. Zhang,
N. Brooijmans,
T. P. LaBranche,
A. Wozniak,
Y. K. Gebreyohannes,
P. Schöffski,
M. C. Heinrich,
D. J. DeAngelo,
S. Miller,
B. Wolf,
N. Kohl,
T. Guzi,
N. Lydon,
A. Boral,
C. Lengauer
, A precision therapy against cancers driven by KIT/PDGFRA mutations. Sci. Transl. Med. 9, eaao1690 (2017).
OpenUrl Abstract/FREE Full Text

[2] E. K. Evans,

[3] A. K. Gardino,

[4] J. L. Kim,

[5] B. L. Hodous,

[6] A. Shutes,

[7] A. Davis,

[8] X. J. Zhu,

[9] O. Schmidt-Kittler,

[10] D. Wilson,

[11] K. Wilson,

[12] L. DiPietro,

[13] Y. Zhang,

[14] N. Brooijmans,

[15] T. P. LaBranche,

[16] A. Wozniak,

[17] Y. K. Gebreyohannes,

[18] P. Schöffski,

[19] M. C. Heinrich,

[20] D. J. DeAngelo,

[21] S. Miller,

[22] B. Wolf,

[23] N. Kohl,

[24] T. Guzi,

[25] N. Lydon,

[26] A. Boral,

[27] C. Lengauer

[28] A. G. Henssen,
C. Reed,
E. Jiang,
H. D. Garcia,
J. von Stebut,
I. C. MacArthur,
P. Hundsdoerfer,
J. H. Kim,
E. de Stanchina,
Y. Kuwahara,
H. Hosoi,
N. J. Ganem,
F. Dela Cruz,
A. L. Kung,
J. H. Schulte,
J. H. Petrini,
A. Kentsis
, Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors. Sci. Transl. Med. 9, eaam9078 (2017).
OpenUrl Abstract/FREE Full Text

[29] A. G. Henssen,

[30] C. Reed,

[31] E. Jiang,

[32] H. D. Garcia,

[33] J. von Stebut,

[34] I. C. MacArthur,

[35] P. Hundsdoerfer,

[36] J. H. Kim,

[37] E. de Stanchina,

[38] Y. Kuwahara,

[39] H. Hosoi,

[40] N. J. Ganem,

[41] F. Dela Cruz,

[42] A. L. Kung,

[43] J. H. Schulte,

[44] J. H. Petrini,

[45] A. Kentsis

Papers of note in Science Translational Medicine 9 (414)

Highlighted Articles

Science Signaling

Article Tools