This week’s articles describe new ways to treat some types of GI cancer and various childhood solid tumors.
CANCER
A targeted KIT inhibitor
Evans et al. show that an active-conformation inhibitor of the kinases KIT and PDGFRA is effective in patients with gastrointestinal cancer.
An Achilles’ heel in childhood cancers
Henssen et al. show that inhibiting nonhomologous end joining–mediated repair of DNA may kill various childhood-associated solid tumors that express the DNA transposase PGBD5.