Editors' ChoiceCellular and Molecular Signaling

Papers of note in Nature 551 (7678)

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Science Signaling  07 Nov 2017:
Vol. 10, Issue 504, eaar3893
DOI: 10.1126/scisignal.aar3893

This week’s papers address the involvement of TGF-β signaling in the differentiation of TH17 cells, a checkpoint that restrains the antitumor and antivirus activities of natural killer cells, and a mechanism for erasing a parental epigenetic memory in plant embryos.


Enabling TH17 differentiation

Zhang et al. found that transforming growth factor–β (TGF-β) signaling is required for the differentiation of T helper 17 (TH17) cells because it derepresses expression of the receptor RORγt.

Unleashing NK cells

Molgora et al. report that knocking out the interleukin receptor IL-1R8 promotes the maturation and antitumor and antivirus activities of natural killer cells.


Erasing parental memories

Tao et al. show that the seed-specific transcription factor LEC1 reprograms the Arabidopsis embryo to erase the epigenetic memory of parental vernalization.

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