Papers of note in Nature 551 (7678)

Annalisa M. VanHook

doi:10.1126/scisignal.aar3893

This week’s papers address the involvement of TGF-β signaling in the differentiation of T_H17 cells, a checkpoint that restrains the antitumor and antivirus activities of natural killer cells, and a mechanism for erasing a parental epigenetic memory in plant embryos.

IMMUNOLOGY

Enabling T_H17 differentiation

Zhang et al. found that transforming growth factor–β (TGF-β) signaling is required for the differentiation of T helper 17 (T_H17) cells because it derepresses expression of the receptor RORγt.

Unleashing NK cells

Molgora et al. report that knocking out the interleukin receptor IL-1R8 promotes the maturation and antitumor and antivirus activities of natural killer cells.

PLANT BIOLOGY

Erasing parental memories

Tao et al. show that the seed-specific transcription factor LEC1 reprograms the Arabidopsis embryo to erase the epigenetic memory of parental vernalization.

Highlighted Articles

1. S. Zhang,
2. M. Takaku,
3. L. Zou,
4. A.-d. Gu,
5. W.-c. Chou,
6. G. Zhang,
7. B. Wu,
8. Q. Kong,
9. S. Y. Thomas,
10. J. S. Serody,
11. X. Chen,
12. X. Xu,
13. P. A. Wade,
14. D. N. Cook,
15. J. P. Y. Ting,
16. Y. Y. Wan
, Reversing SKI–SMAD4-mediated suppression is essential for T_H17 cell differentiation. Nature 551, 105–109 (2017).
OpenUrl
1. M. Molgora,
2. E. Bonavita,
3. A. Ponzetta,
4. F. Riva,
5. M. Barbagallo,
6. S. Jaillon,
7. B. Popović,
8. G. Bernardini,
9. E. Magrini,
10. F. Gianni,
11. S. Zelenay,
12. S. Jonjić,
13. A. Santoni,
14. C. Garlanda,
15. A. Mantovani
, IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity. Nature 551, 110–114 (2017).
OpenUrl
1. Z. Tao,
2. L. Shen,
3. X. Gu,
4. Y. Wang,
5. H. Yu,
6. Y. He
, Embryonic epigenetic reprogramming by a pioneer transcription factor in plants. Nature 551, 124–128 (2017).
OpenUrl

View Abstract

[1] S. Zhang,
M. Takaku,
L. Zou,
A.-d. Gu,
W.-c. Chou,
G. Zhang,
B. Wu,
Q. Kong,
S. Y. Thomas,
J. S. Serody,
X. Chen,
X. Xu,
P. A. Wade,
D. N. Cook,
J. P. Y. Ting,
Y. Y. Wan
, Reversing SKI–SMAD4-mediated suppression is essential for T_H17 cell differentiation. Nature 551, 105–109 (2017).
OpenUrl

[2] S. Zhang,

[3] M. Takaku,

[4] L. Zou,

[5] A.-d. Gu,

[6] W.-c. Chou,

[7] G. Zhang,

[8] B. Wu,

[9] Q. Kong,

[10] S. Y. Thomas,

[11] J. S. Serody,

[12] X. Chen,

[13] X. Xu,

[14] P. A. Wade,

[15] D. N. Cook,

[16] J. P. Y. Ting,

[17] Y. Y. Wan

[18] M. Molgora,
E. Bonavita,
A. Ponzetta,
F. Riva,
M. Barbagallo,
S. Jaillon,
B. Popović,
G. Bernardini,
E. Magrini,
F. Gianni,
S. Zelenay,
S. Jonjić,
A. Santoni,
C. Garlanda,
A. Mantovani
, IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity. Nature 551, 110–114 (2017).
OpenUrl

[19] M. Molgora,

[20] E. Bonavita,

[21] A. Ponzetta,

[22] F. Riva,

[23] M. Barbagallo,

[24] S. Jaillon,

[25] B. Popović,

[26] G. Bernardini,

[27] E. Magrini,

[28] F. Gianni,

[29] S. Zelenay,

[30] S. Jonjić,

[31] A. Santoni,

[32] C. Garlanda,

[33] A. Mantovani

[34] Z. Tao,
L. Shen,
X. Gu,
Y. Wang,
H. Yu,
Y. He
, Embryonic epigenetic reprogramming by a pioneer transcription factor in plants. Nature 551, 124–128 (2017).
OpenUrl

[35] Z. Tao,

[36] L. Shen,

[37] X. Gu,

[38] Y. Wang,

[39] H. Yu,

[40] Y. He

Papers of note in Nature 551 (7678)

Highlighted Articles

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