Contents
14 November 2017
Vol 10, Issue 505
Vol 10, Issue 505
Research Article
- MAFB enhances oncogenic Notch signaling in T cell acute lymphoblastic leukemia
The transcription factor MAFB epigenetically facilitates Notch1-induced T cell leukemia.
Research Resource
- Generation of specific inhibitors of SUMO-1– and SUMO-2/3–mediated protein-protein interactions using Affimer (Adhiron) technology
Artificial binding proteins are tools for exploring cellular processes dependent on SUMOylation.
Review
- The genetics of PKMζ and memory maintenance
Two atypical PKC isoforms can compensate for each other during short- and long-term memory.
Protocol
- Isolation of isoform-specific binding proteins (Affimers) by phage display using negative selection
A Protocol describes how to isolate artificial binding proteins (Affimers) that differentiate between closely related targets.
Editors' Choice
- Fat expansion through norepinephrine catabolism
Certain macrophage populations limit norepinephrine-induced lipolysis in adipose tissues in response to aging or obesity.
- Papers of note in Science 358 (6364)
This week’s articles highlight a newly identified component of methionine sensing; a mechanism by which nutrient depletion prevents the efflux of essential amino acids from lysosomes; how reactive oxygen species promote genome stability during metabolic stress; co-option of the cell cycle regulatory machinery to time the differentiation of multiciliated cells; and connections between olfaction, organismal metabolism, and longevity.
- Papers of note in Science Translational Medicine 9 (415)
This week’s articles describe a way to combat the negative effects of stress on cancer therapy; a potential target in heart failure; and why nighttime wounds heal more slowly than daytime wounds.
- Papers of note in Nature 551 (7679)
This week’s articles highlight interactions between astrocytes and neurons that influence both cell types’ form and function; a genetic basis for individual variation in aging; and the mechanism by which an E3 ubiquitin ligase adaptor affects synaptic transmission.
About The Cover
Online Cover This week features a Review that describes how two atypical PKC isoforms, PKMζ and PKCι/λ, can compensate for each other during short- and long-term memory. Memory formation requires a persistent strengthening of excitatory transmission at specific synapses. The image shows an artist's rendering of synaptic transmission. [Image: Rost9/shutterstock]