Research ArticleLEUKEMIA
MAFB enhances oncogenic Notch signaling in T cell acute lymphoblastic leukemia
- View ORCID ProfileKostandin V. Pajcini1,2,3,*,
- View ORCID ProfileLanwei Xu2,3,
- View ORCID ProfileLijian Shao1,
- View ORCID ProfileJelena Petrovic2,3,
- View ORCID ProfileKarol Palasiewicz1,
- View ORCID ProfileYumi Ohtani2,3,
- View ORCID ProfileWill Bailis2,3,
- View ORCID ProfileCurtis Lee2,3,
- Gerald B. Wertheim3,
- View ORCID ProfileRajeswaran Mani4,
- View ORCID ProfileNatarajan Muthusamy4,
- View ORCID ProfileYunlei Li5,
- View ORCID ProfileJules P. P. Meijerink6,
- View ORCID ProfileStephen C. Blacklow7,
- View ORCID ProfileRobert B. Faryabi2,3,
- Sara Cherry8, and
- View ORCID ProfileWarren S. Pear2,3,*
- 1Department of Pharmacology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
- 2Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 3Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 4The James, Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.
- 5Department of Pediatric Oncology/Hematology, Erasmus Medical Center, Rotterdam, Netherlands.
- 6Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands.
- 7Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
- 8Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
- ↵*Corresponding author. Email: kvp{at}uic.edu (K.V.P.); wpear{at}pennmedicine.upenn.edu (W.S.P.)
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Science Signaling 14 Nov 2017:
Vol. 10, Issue 505, eaam6846
DOI: 10.1126/scisignal.aam6846
Vol. 10, Issue 505, eaam6846
DOI: 10.1126/scisignal.aam6846
Kostandin V. Pajcini
1Department of Pharmacology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
2Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
3Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Lanwei Xu
2Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
3Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Lijian Shao
1Department of Pharmacology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
Jelena Petrovic
2Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
3Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Karol Palasiewicz
1Department of Pharmacology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
Yumi Ohtani
2Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
3Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Will Bailis
2Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
3Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Curtis Lee
2Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
3Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Gerald B. Wertheim
3Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Rajeswaran Mani
4The James, Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.
Natarajan Muthusamy
4The James, Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.
Yunlei Li
5Department of Pediatric Oncology/Hematology, Erasmus Medical Center, Rotterdam, Netherlands.
Jules P. P. Meijerink
6Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands.
Stephen C. Blacklow
7Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Robert B. Faryabi
2Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
3Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Sara Cherry
8Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Warren S. Pear
2Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
3Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
