This week’s articles highlight a newly identified component of methionine sensing; a mechanism by which nutrient depletion prevents the efflux of essential amino acids from lysosomes; how reactive oxygen species promote genome stability during metabolic stress; co-option of the cell cycle regulatory machinery to time the differentiation of multiciliated cells; and connections between olfaction, organismal metabolism, and longevity.
NUTRIENT SENSING
SAMTOR joins the family
Gu et al. show that SAMTOR is a SAM sensor that links methionine and one-carbon metabolism to mTORC1 signaling.
METABOLISM
Regulated lysosomal efflux of amino acids
Abu-Remaileh et al. developed a method for the rapid isolation of lysosomes and elucidated the mechanism of regulated amino acid transport.
DNA REPLICATION
Metabolic regulation of genome stability
Somyajit et al. demonstrate that reactive oxygen species slow down the speed of DNA replication, thereby protecting genome integrity under metabolic stress (see also Gómez-González and Aguilera).
CELL BIOLOGY
Taming mitosis for differentiation
Al Jord et al. found that multiciliated cells co-opt the cell cycle regulatory machinery during differentiation to generate hundreds of cell surface cilia (see also Levine and Holland).
NEUROENDOCRINOLOGY
Connecting smell to metabolism
Garrison and Knight discuss how the olfactory system can have direct effects on energy homeostasis.
