Editors' ChoiceCellular and Molecular Signaling

Papers of note in Science 358 (6364)

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Science Signaling  14 Nov 2017:
Vol. 10, Issue 505, eaar4559
DOI: 10.1126/scisignal.aar4559

This week’s articles highlight a newly identified component of methionine sensing; a mechanism by which nutrient depletion prevents the efflux of essential amino acids from lysosomes; how reactive oxygen species promote genome stability during metabolic stress; co-option of the cell cycle regulatory machinery to time the differentiation of multiciliated cells; and connections between olfaction, organismal metabolism, and longevity.


SAMTOR joins the family

Gu et al. show that SAMTOR is a SAM sensor that links methionine and one-carbon metabolism to mTORC1 signaling.


Regulated lysosomal efflux of amino acids

Abu-Remaileh et al. developed a method for the rapid isolation of lysosomes and elucidated the mechanism of regulated amino acid transport.


Metabolic regulation of genome stability

Somyajit et al. demonstrate that reactive oxygen species slow down the speed of DNA replication, thereby protecting genome integrity under metabolic stress (see also Gómez-González and Aguilera).


Taming mitosis for differentiation

Al Jord et al. found that multiciliated cells co-opt the cell cycle regulatory machinery during differentiation to generate hundreds of cell surface cilia (see also Levine and Holland).


Connecting smell to metabolism

Garrison and Knight discuss how the olfactory system can have direct effects on energy homeostasis.

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