Research ArticleLABOR

AKAP95-mediated nuclear anchoring of PKA mediates cortisol-induced PTGS2 expression in human amnion fibroblasts

See allHide authors and affiliations

Science Signaling  21 Nov 2017:
Vol. 10, Issue 506, eaac6160
DOI: 10.1126/scisignal.aac6160

PKA labors in the nucleus

Stress hormone signaling is associated with the induction of labor in pregnancy. The stress hormone cortisol stimulates the production of the enzyme COX-2 in fetal membrane cells through induction of the transcription factor CREB. COX-2 produces prostaglandins, which generate positive feedback on the cells to produce more. Lu et al. found that the selective localization of the kinase PKA in the nucleus is critical to this mechanism in the fetal membranes. In human amnion fibroblasts taken from normal “term”-labor deliveries, compared to those from cesarean sections, the localization of PKA in the nucleus by interaction with AKAP95 enabled it to phosphorylate and activate CREB. These findings reveal additional molecular targets through which clinicians might induce labor or prevent it from initiating prematurely. The nuclear localization of PKA-AKAP95 introduces a new subcellular role for PKA signaling, potentially restricted to these highly specialized cells.

View Full Text

Stay Connected to Science Signaling