Research ArticleCell Migration

ATP promotes the fast migration of dendritic cells through the activity of pannexin 1 channels and P2X7 receptors

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Science Signaling  21 Nov 2017:
Vol. 10, Issue 506, eaah7107
DOI: 10.1126/scisignal.aah7107

ATP increases dendritic cell speed

When dendritic cells (DCs) in peripheral tissues encounter danger-associated signals, such as microbial products or ATP released from damaged cells, they migrate to lymph nodes to activate T cells and initiate the adaptive immune response. Sáez et al. found that ATP stimulated P2X7 receptors in DCs, which resulted in the opening of pannexin 1 (Panx1) channels and the release of ATP as part of an autocrine loop that increased DC migration speed. DCs from Panx1-deficient mice migrated more slowly than did DCs from wild-type mice. When injected into the footpads of mice, ATP-treated Panx1-deficient DCs exhibited defective migration to draining lymph nodes. Together, these data suggest that P2X7 receptors and Panx1 channels facilitate the speedy migration of DCs to lymph nodes in response to danger signals.

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