Research ArticleMechanotransduction
Microtubules tune mechanotransduction through NOX2 and TRPV4 to decrease sclerostin abundance in osteocytes
- View ORCID ProfileJames S. Lyons1,
- View ORCID ProfileHumberto C. Joca2,
- Robert A. Law3,
- Katrina M. Williams1,
- Jaclyn P. Kerr4,
- Guoli Shi4,
- View ORCID ProfileRamzi J. Khairallah5,
- Stuart S. Martin6,
- Konstantinos Konstantopoulos3,
- View ORCID ProfileChristopher W. Ward4,*, and
- View ORCID ProfileJoseph P. Stains1,*
- 1Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
- 2Center for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
- 3Department of Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
- 4Department of Orthopaedics, University of Maryland School of Nursing, Baltimore, MD 21201, USA.
- 5Myologica, LLC, New Market, MD 21212, USA.
- 6Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
- ↵*Corresponding author. Email: jstains{at}som.umaryland.edu (J.P.S.); ward{at}umaryland.edu (C.W.W.)
See allHide authors and affiliations
Science Signaling 21 Nov 2017:
Vol. 10, Issue 506, eaan5748
DOI: 10.1126/scisignal.aan5748
Vol. 10, Issue 506, eaan5748
DOI: 10.1126/scisignal.aan5748
James S. Lyons
1Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Humberto C. Joca
2Center for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Robert A. Law
3Department of Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Katrina M. Williams
1Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Jaclyn P. Kerr
4Department of Orthopaedics, University of Maryland School of Nursing, Baltimore, MD 21201, USA.
Guoli Shi
4Department of Orthopaedics, University of Maryland School of Nursing, Baltimore, MD 21201, USA.
Ramzi J. Khairallah
5Myologica, LLC, New Market, MD 21212, USA.
Stuart S. Martin
6Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Konstantinos Konstantopoulos
3Department of Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Christopher W. Ward
4Department of Orthopaedics, University of Maryland School of Nursing, Baltimore, MD 21201, USA.
Joseph P. Stains
1Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
