Research ArticleFibrosis
Nuclear hyaluronidase 2 drives alternative splicing of CD44 pre-mRNA to determine profibrotic or antifibrotic cell phenotype
- Adam C. Midgley1,
- Sebastian Oltean2,
- Vincent Hascall3,
- Emma L. Woods1,
- Robert Steadman1,
- Aled O. Phillips1, and
- Soma Meran1,*
- 1Wales Kidney Research Unit, Systems Immunity University Research Institute, Division of Infection and Immunity, College of Biomedical and Life Sciences, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
- 2Institute of Biomedical and Clinical Sciences, University of Exeter Medical School,Exeter EX1 2LU, UK.
- 3Department of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
- ↵*Corresponding author. Email: merans{at}cf.ac.uk
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Science Signaling 21 Nov 2017:
Vol. 10, Issue 506, eaao1822
DOI: 10.1126/scisignal.aao1822
Vol. 10, Issue 506, eaao1822
DOI: 10.1126/scisignal.aao1822
Adam C. Midgley
Wales Kidney Research Unit, Systems Immunity University Research Institute, Division of Infection and Immunity, College of Biomedical and Life Sciences, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
Sebastian Oltean
Institute of Biomedical and Clinical Sciences, University of Exeter Medical School,Exeter EX1 2LU, UK.
Vincent Hascall
Department of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Emma L. Woods
Wales Kidney Research Unit, Systems Immunity University Research Institute, Division of Infection and Immunity, College of Biomedical and Life Sciences, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
Robert Steadman
Wales Kidney Research Unit, Systems Immunity University Research Institute, Division of Infection and Immunity, College of Biomedical and Life Sciences, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
Aled O. Phillips
Wales Kidney Research Unit, Systems Immunity University Research Institute, Division of Infection and Immunity, College of Biomedical and Life Sciences, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
Soma Meran
Wales Kidney Research Unit, Systems Immunity University Research Institute, Division of Infection and Immunity, College of Biomedical and Life Sciences, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
