This week’s articles identify a mechanism by which liver inflammation suppresses antitumor immunity; a bacterial effector protein that targets host defense proteins for degradation; and a signaling mechanism for detecting and repairing a specific type of DNA damage.
CANCER IMMUNOLOGY
Inflammation inhibits antitumor immunity
Shalapour et al. demonstrate that a subset of B cells contributes to the development of hepatocellular carcinoma in mice and humans with nonalcoholic fatty liver disease by suppressing the activation of antitumor T cells.
HOST-PATHOGEN INTERACTIONS
Targeting GBPs to disrupt host defense
Li et al. report that a Shigella flexneri effector protein targets host antimicrobial guanylate-binding proteins for degradation (see also commentary by MacMicking).
DNA REPAIR
Undoing alkylation damage
Brickner et al. describe a ubiquitin-dependent signaling mechanism for detecting and repairing DNA alkylation.