Papers of note in Nature 551 (7680)

Annalisa M. VanHook

doi:10.1126/scisignal.aar5179

This week’s articles identify a mechanism by which liver inflammation suppresses antitumor immunity; a bacterial effector protein that targets host defense proteins for degradation; and a signaling mechanism for detecting and repairing a specific type of DNA damage.

CANCER IMMUNOLOGY

Inflammation inhibits antitumor immunity

Shalapour et al. demonstrate that a subset of B cells contributes to the development of hepatocellular carcinoma in mice and humans with nonalcoholic fatty liver disease by suppressing the activation of antitumor T cells.

HOST-PATHOGEN INTERACTIONS

Targeting GBPs to disrupt host defense

Li et al. report that a Shigella flexneri effector protein targets host antimicrobial guanylate-binding proteins for degradation (see also commentary by MacMicking).

DNA REPAIR

Undoing alkylation damage

Brickner et al. describe a ubiquitin-dependent signaling mechanism for detecting and repairing DNA alkylation.

Highlighted Articles

1. S. Shalapour,
2. X.-J. Lin,
3. I. N. Bastian,
4. J. Brain,
5. A. D. Burt,
6. A. A. Aksenov,
7. A. F. Vrbanac,
8. W. Li,
9. A. Perkins,
10. T. Matsutani,
11. Z. Zhong,
12. D. Dhar,
13. J. A. Navas-Molina,
14. J. Xu,
15. R. Loomba,
16. M. Downes,
17. R. T. Yu,
18. R. M. Evans,
19. P. C. Dorrestein,
20. R. Knight,
21. C. Benner,
22. Q. M. Anstee,
23. M. Karin
, Inflammation-induced IgA⁺ cells dismantle anti-liver cancer immunity. Nature 551, 340–345 (2017).
OpenUrl
1. P. Li,
2. W. Jiang,
3. Q. Yu,
4. W. Liu,
5. P. Zhou,
6. J. Li,
7. J. Xu,
8. B. Xu,
9. F. Wang,
10. F. Shao
, Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence. Nature 551, 378–383 (2017).
OpenUrl
1. J. D. MacMicking
, Bacteria disarm host-defence proteins. Nature 551, 303–305 (2017).
OpenUrl
1. J. R. Brickner,
2. J. M. Soll,
3. P. M. Lombardi,
4. C. B. Vågbø,
5. M. C. Mudge,
6. C. Oyeniran,
7. R. Rabe,
8. J. Jackson,
9. M. E. Sullender,
10. E. Blazosky,
11. A. K. Byrum,
12. Y. Zhao,
13. M. A. Corbett,
14. J. Gécz,
15. M. Field,
16. A. Vindigni,
17. G. Slupphaug,
18. C. Wolberger,
19. N. Mosammaparast
, A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair. Nature 551, 389–393 (2017).
OpenUrl

[1] S. Shalapour,
X.-J. Lin,
I. N. Bastian,
J. Brain,
A. D. Burt,
A. A. Aksenov,
A. F. Vrbanac,
W. Li,
A. Perkins,
T. Matsutani,
Z. Zhong,
D. Dhar,
J. A. Navas-Molina,
J. Xu,
R. Loomba,
M. Downes,
R. T. Yu,
R. M. Evans,
P. C. Dorrestein,
R. Knight,
C. Benner,
Q. M. Anstee,
M. Karin
, Inflammation-induced IgA⁺ cells dismantle anti-liver cancer immunity. Nature 551, 340–345 (2017).
OpenUrl

[2] S. Shalapour,

[3] X.-J. Lin,

[4] I. N. Bastian,

[5] J. Brain,

[6] A. D. Burt,

[7] A. A. Aksenov,

[8] A. F. Vrbanac,

[9] W. Li,

[10] A. Perkins,

[11] T. Matsutani,

[12] Z. Zhong,

[13] D. Dhar,

[14] J. A. Navas-Molina,

[15] J. Xu,

[16] R. Loomba,

[17] M. Downes,

[18] R. T. Yu,

[19] R. M. Evans,

[20] P. C. Dorrestein,

[21] R. Knight,

[22] C. Benner,

[23] Q. M. Anstee,

[24] M. Karin

[25] P. Li,
W. Jiang,
Q. Yu,
W. Liu,
P. Zhou,
J. Li,
J. Xu,
B. Xu,
F. Wang,
F. Shao
, Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence. Nature 551, 378–383 (2017).
OpenUrl

[26] P. Li,

[27] W. Jiang,

[28] Q. Yu,

[29] W. Liu,

[30] P. Zhou,

[31] J. Li,

[32] J. Xu,

[33] B. Xu,

[34] F. Wang,

[35] F. Shao

[36] J. D. MacMicking
, Bacteria disarm host-defence proteins. Nature 551, 303–305 (2017).
OpenUrl

[37] J. D. MacMicking

[38] J. R. Brickner,
J. M. Soll,
P. M. Lombardi,
C. B. Vågbø,
M. C. Mudge,
C. Oyeniran,
R. Rabe,
J. Jackson,
M. E. Sullender,
E. Blazosky,
A. K. Byrum,
Y. Zhao,
M. A. Corbett,
J. Gécz,
M. Field,
A. Vindigni,
G. Slupphaug,
C. Wolberger,
N. Mosammaparast
, A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair. Nature 551, 389–393 (2017).
OpenUrl

[39] J. R. Brickner,

[40] J. M. Soll,

[41] P. M. Lombardi,

[42] C. B. Vågbø,

[43] M. C. Mudge,

[44] C. Oyeniran,

[45] R. Rabe,

[46] J. Jackson,

[47] M. E. Sullender,

[48] E. Blazosky,

[49] A. K. Byrum,

[50] Y. Zhao,

[51] M. A. Corbett,

[52] J. Gécz,

[53] M. Field,

[54] A. Vindigni,

[55] G. Slupphaug,

[56] C. Wolberger,

[57] N. Mosammaparast

Papers of note in Nature 551 (7680)

Highlighted Articles

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