28 November 2017
Vol 10, Issue 507

About The Cover

Cover image expansion

Online Cover This week features a Research Article that reveals the multistep gating mechanism for the calcium-release activated calcium (CRAC) channel Orai1 through the characterization of disease-associated mutants (see also the accompanying Focus). The image shows a representative snapshot of the equilibrated part of a molecular dynamics simulation for wild-type Orai1. [Image: Frischauf et al./Science Signaling]