Research ArticleBiochemistry
Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis
- View ORCID ProfileSarah N. Lauder1,2,
- Keith Allen-Redpath1,2,*,
- View ORCID ProfileDavid A. Slatter1,2,*,
- Maceler Aldrovandi1,2,
- Anne O’Connor1,2,
- View ORCID ProfileDaniel Farewell3,
- View ORCID ProfileCharles L. Percy1,2,
- Jessica E. Molhoek4,
- View ORCID ProfileSirpa Rannikko5,6,
- Victoria J. Tyrrell1,2,
- View ORCID ProfileSalvatore Ferla7,
- View ORCID ProfileGinger L. Milne8,
- View ORCID ProfileAlastair W. Poole9,
- View ORCID ProfileChristopher P. Thomas1,2,7,
- Samya Obaji1,2,
- View ORCID ProfilePhilip R. Taylor1,2,
- View ORCID ProfileSimon A. Jones1,2,
- Phillip G. de Groot4,
- View ORCID ProfileRolf T. Urbanus4,
- View ORCID ProfileSohvi Hörkkö5,6,
- View ORCID ProfileStefan Uderhardt10,
- Jochen Ackermann10,
- P. Vince Jenkins11,
- Andrea Brancale7,
- Gerhard Krönke10,
- View ORCID ProfilePeter W. Collins1,2,†, and
- View ORCID ProfileValerie B. O’Donnell1,2,†
- 1Systems Immunity Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
- 2Division of Infection and Immunity, Cardiff University, Cardiff CF14 4XN, UK.
- 3Division of Population Medicine, Cardiff University, Cardiff CF14 4XN, UK.
- 4Department of Clinical Chemistry and Haematology, University of Utrecht, University Medical Center Utrecht, Utrecht 3584 CX, Netherlands.
- 5Department of Medical Microbiology and Immunology, Research Unit of Biomedicine, Finland and Medical Research Center, University of Oulu, P.O. Box 5000, Oulu 90220, Finland.
- 6Nordlab Oulu, University Hospital, Oulu 90220, Finland.
- 7Welsh School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF14 4XN, UK.
- 8Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37240, USA.
- 9School of Physiology, Pharmacy and Neuroscience, Medical Sciences Building, University Walk, Bristol BS8 1TD, UK.
- 10Department of Internal Medicine and Institute for Clinical Immunology, University Hospital Erlangen, Erlangen, Germany.
- 11Institute of Molecular Medicine, St James’s Hospital, Dublin, Ireland.
- ↵†Corresponding author. Email: o-donnellvb{at}cardiff.ac.uk (V.B.O.); collinspw{at}cardiff.ac.uk (P.W.C.)
↵* These authors contributed equally to this work.
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Science Signaling 28 Nov 2017:
Vol. 10, Issue 507, eaan2787
DOI: 10.1126/scisignal.aan2787
Vol. 10, Issue 507, eaan2787
DOI: 10.1126/scisignal.aan2787
Sarah N. Lauder
1Systems Immunity Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
2Division of Infection and Immunity, Cardiff University, Cardiff CF14 4XN, UK.
Keith Allen-Redpath
1Systems Immunity Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
2Division of Infection and Immunity, Cardiff University, Cardiff CF14 4XN, UK.
David A. Slatter
1Systems Immunity Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
2Division of Infection and Immunity, Cardiff University, Cardiff CF14 4XN, UK.
Maceler Aldrovandi
1Systems Immunity Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
2Division of Infection and Immunity, Cardiff University, Cardiff CF14 4XN, UK.
Anne O’Connor
1Systems Immunity Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
2Division of Infection and Immunity, Cardiff University, Cardiff CF14 4XN, UK.
Daniel Farewell
3Division of Population Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Charles L. Percy
1Systems Immunity Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
2Division of Infection and Immunity, Cardiff University, Cardiff CF14 4XN, UK.
Jessica E. Molhoek
4Department of Clinical Chemistry and Haematology, University of Utrecht, University Medical Center Utrecht, Utrecht 3584 CX, Netherlands.
Sirpa Rannikko
5Department of Medical Microbiology and Immunology, Research Unit of Biomedicine, Finland and Medical Research Center, University of Oulu, P.O. Box 5000, Oulu 90220, Finland.
6Nordlab Oulu, University Hospital, Oulu 90220, Finland.
Victoria J. Tyrrell
1Systems Immunity Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
2Division of Infection and Immunity, Cardiff University, Cardiff CF14 4XN, UK.
Salvatore Ferla
7Welsh School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF14 4XN, UK.
Ginger L. Milne
8Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37240, USA.
Alastair W. Poole
9School of Physiology, Pharmacy and Neuroscience, Medical Sciences Building, University Walk, Bristol BS8 1TD, UK.
Christopher P. Thomas
1Systems Immunity Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
2Division of Infection and Immunity, Cardiff University, Cardiff CF14 4XN, UK.
7Welsh School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF14 4XN, UK.
Samya Obaji
1Systems Immunity Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
2Division of Infection and Immunity, Cardiff University, Cardiff CF14 4XN, UK.
Philip R. Taylor
1Systems Immunity Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
2Division of Infection and Immunity, Cardiff University, Cardiff CF14 4XN, UK.
Simon A. Jones
1Systems Immunity Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
2Division of Infection and Immunity, Cardiff University, Cardiff CF14 4XN, UK.
Phillip G. de Groot
4Department of Clinical Chemistry and Haematology, University of Utrecht, University Medical Center Utrecht, Utrecht 3584 CX, Netherlands.
Rolf T. Urbanus
4Department of Clinical Chemistry and Haematology, University of Utrecht, University Medical Center Utrecht, Utrecht 3584 CX, Netherlands.
Sohvi Hörkkö
5Department of Medical Microbiology and Immunology, Research Unit of Biomedicine, Finland and Medical Research Center, University of Oulu, P.O. Box 5000, Oulu 90220, Finland.
6Nordlab Oulu, University Hospital, Oulu 90220, Finland.
Stefan Uderhardt
10Department of Internal Medicine and Institute for Clinical Immunology, University Hospital Erlangen, Erlangen, Germany.
Jochen Ackermann
10Department of Internal Medicine and Institute for Clinical Immunology, University Hospital Erlangen, Erlangen, Germany.
P. Vince Jenkins
11Institute of Molecular Medicine, St James’s Hospital, Dublin, Ireland.
Andrea Brancale
7Welsh School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF14 4XN, UK.
Gerhard Krönke
10Department of Internal Medicine and Institute for Clinical Immunology, University Hospital Erlangen, Erlangen, Germany.
Peter W. Collins
1Systems Immunity Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
2Division of Infection and Immunity, Cardiff University, Cardiff CF14 4XN, UK.
Valerie B. O’Donnell
1Systems Immunity Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
2Division of Infection and Immunity, Cardiff University, Cardiff CF14 4XN, UK.
