Contents
12 December 2017
Vol 10, Issue 509
Vol 10, Issue 509
Research Articles
- Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes
Age-related reduction of the adaptor protein TRAF3 compromises the innate immune response of monocytes from older individuals.
- RhoB controls the Rab11-mediated recycling and surface reappearance of LFA-1 in migrating T lymphocytes
Imaging analysis reveals a mechanism for the integrin recycling required to maintain T cell migration.
- C-reactive protein promotes bone destruction in human myeloma through the CD32–p38 MAPK–Twist axis
Liver-secreted C-reactive protein is not just a biomarker of myeloma, it promotes myeloma-associated bone loss in patients.
Editors' Choice
- Generating heat through Ca2+ cycling
Beige fat regulates whole-body energy homeostasis by cycling Ca2+ through RyR2 and SERCA2b.
- Papers of note in Science 358 (6368)
This week’s articles report that inhibiting the ion channel TRPC5 prevents the loss of podocytes in rat models of kidney disease.
- Paper of note in Science Translational Medicine 9 (419)
This week’s article describes a way to potentially reduce neurodegeneration in patients with Huntington’s disease.
- Papers of note in Nature 552 (7683)
This week’s articles highlight a potential therapeutic target for fibrosis; parasite receptors that contribute to malaria; a potential drawback of PD-1 inhibition for cancer immunotherapy; a noncoding RNA that regulates ribosome biogenesis; and a structural analysis of substrate binding by the kinase PINK1.
About The Cover
Online Cover This week features a Research Article that shows why monocytes from older adults exhibit a less robust innate immune response than monocytes from younger adults, which contributes to the increased susceptibility of older adults to death resulting from influenza A virus infection. The image shows an influenza virus. [Image: BSIP SA/Alamy Stock Photo]