Paper of note in Science Translational Medicine 9 (419)

Leslie K. Ferrarelli

doi:10.1126/scisignal.aar6876

Article
Info & Metrics
eLetters

This week’s article describes a way to potentially reduce neurodegeneration in patients with Huntington’s disease.

HUNTINGTON’S DISEASE

Defeating neurotoxicity with a repurposed drug

Dickey et al. report that agonists of the nuclear receptors RXR and PPARδ are neuroprotective in models of Huntington’s disease because they enhance oxidative metabolism and promote autophagy-mediated protein homeostasis.

Highlighted Article

1. A. S. Dickey,
2. D. N. Sanchez,
3. M. Arreola,
4. K. R. Sampat,
5. W. Fan,
6. N. Arbez,
7. S. Akimov,
8. M. J. Van Kanegan,
9. K. Ohnishi,
10. S. K. Gilmore-Hall,
11. A. L. Flores,
12. J. M. Nguyen,
13. N. Lomas,
14. C. L. Hsu,
15. D. C. Lo,
16. C. A. Ross,
17. E. Masliah,
18. R. M. Evans,
19. A. R. La Spada
, PPARδ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis. Sci. Transl. Med. 9, eaal2332 (2017).
OpenUrl Abstract/FREE Full Text

View Abstract

[1] A. S. Dickey,
D. N. Sanchez,
M. Arreola,
K. R. Sampat,
W. Fan,
N. Arbez,
S. Akimov,
M. J. Van Kanegan,
K. Ohnishi,
S. K. Gilmore-Hall,
A. L. Flores,
J. M. Nguyen,
N. Lomas,
C. L. Hsu,
D. C. Lo,
C. A. Ross,
E. Masliah,
R. M. Evans,
A. R. La Spada
, PPARδ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis. Sci. Transl. Med. 9, eaal2332 (2017).
OpenUrl Abstract/FREE Full Text

[2] A. S. Dickey,

[3] D. N. Sanchez,

[4] M. Arreola,

[5] K. R. Sampat,

[6] W. Fan,

[7] N. Arbez,

[8] S. Akimov,

[9] M. J. Van Kanegan,

[10] K. Ohnishi,

[11] S. K. Gilmore-Hall,

[12] A. L. Flores,

[13] J. M. Nguyen,

[14] N. Lomas,

[15] C. L. Hsu,

[16] D. C. Lo,

[17] C. A. Ross,

[18] E. Masliah,

[19] R. M. Evans,

[20] A. R. La Spada

Paper of note in Science Translational Medicine 9 (419)

Highlighted Article

Science Signaling

Article Tools

Paper of note in Science Translational Medicine 9 (419)

Citation Manager Formats

Paper of note in Science Translational Medicine 9 (419)

My saved folders

Stay Connected to Science Signaling

Citing Articles in:

share

Highlighted Article

Science Signaling

Article Tools

Paper of note in Science Translational Medicine 9 (419)

Citation Manager Formats

Paper of note in Science Translational Medicine 9 (419)

My saved folders

Stay Connected to Science Signaling

Related Content

Similar Articles in:

Citing Articles in:

Navigate This Article

Read the Latest Issue of Science

22 May 2020

Feature

Research Ethics: COVID-19

Entomology

SCI COMMUN

Public Health

Working Life