This week’s article describes a way to potentially reduce neurodegeneration in patients with Huntington’s disease.
HUNTINGTON’S DISEASE
Defeating neurotoxicity with a repurposed drug
Dickey et al. report that agonists of the nuclear receptors RXR and PPARδ are neuroprotective in models of Huntington’s disease because they enhance oxidative metabolism and promote autophagy-mediated protein homeostasis.