Paper of note in Science Translational Medicine 9 (419)

Leslie K. Ferrarelli

doi:10.1126/scisignal.aar6876

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This week’s article describes a way to potentially reduce neurodegeneration in patients with Huntington’s disease.

HUNTINGTON’S DISEASE

Defeating neurotoxicity with a repurposed drug

Dickey et al. report that agonists of the nuclear receptors RXR and PPARδ are neuroprotective in models of Huntington’s disease because they enhance oxidative metabolism and promote autophagy-mediated protein homeostasis.

Highlighted Article

1. A. S. Dickey,
2. D. N. Sanchez,
3. M. Arreola,
4. K. R. Sampat,
5. W. Fan,
6. N. Arbez,
7. S. Akimov,
8. M. J. Van Kanegan,
9. K. Ohnishi,
10. S. K. Gilmore-Hall,
11. A. L. Flores,
12. J. M. Nguyen,
13. N. Lomas,
14. C. L. Hsu,
15. D. C. Lo,
16. C. A. Ross,
17. E. Masliah,
18. R. M. Evans,
19. A. R. La Spada
, PPARδ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis. Sci. Transl. Med. 9, eaal2332 (2017).
OpenUrl Abstract/FREE Full Text

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[1] A. S. Dickey,
D. N. Sanchez,
M. Arreola,
K. R. Sampat,
W. Fan,
N. Arbez,
S. Akimov,
M. J. Van Kanegan,
K. Ohnishi,
S. K. Gilmore-Hall,
A. L. Flores,
J. M. Nguyen,
N. Lomas,
C. L. Hsu,
D. C. Lo,
C. A. Ross,
E. Masliah,
R. M. Evans,
A. R. La Spada
, PPARδ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis. Sci. Transl. Med. 9, eaal2332 (2017).
OpenUrl Abstract/FREE Full Text

[2] A. S. Dickey,

[3] D. N. Sanchez,

[4] M. Arreola,

[5] K. R. Sampat,

[6] W. Fan,

[7] N. Arbez,

[8] S. Akimov,

[9] M. J. Van Kanegan,

[10] K. Ohnishi,

[11] S. K. Gilmore-Hall,

[12] A. L. Flores,

[13] J. M. Nguyen,

[14] N. Lomas,

[15] C. L. Hsu,

[16] D. C. Lo,

[17] C. A. Ross,

[18] E. Masliah,

[19] R. M. Evans,

[20] A. R. La Spada

Paper of note in Science Translational Medicine 9 (419)

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