Papers of note in Science 358 (6368)

Annalisa M. VanHook

doi:10.1126/scisignal.aar6886

This week’s articles report that inhibiting the ion channel TRPC5 prevents the loss of podocytes in rat models of kidney disease.

NEPHROLOGY

Gaining a foothold on kidney disease?

Zhou et al. report on a drug that inhibits kidney disease in rat models by preventing the loss of podocytes, cells critical for blood filtration (see also Chung and Shaw).

Highlighted Articles

1. Y. Zhou,
2. P. Castonguay,
3. E.-H. Sidhom,
4. A. R. Clark,
5. M. Dvela-Levitt,
6. S. Kim,
7. J. Sieber,
8. N. Wieder,
9. J. Y. Jung,
10. S. Andreeva,
11. J. Reichardt,
12. F. Dubois,
13. S. C. Hoffmann,
14. J. M. Basgen,
15. M. S. Montesinos,
16. A. Weins,
17. A. C. Johnson,
18. E. S. Lander,
19. M. R. Garrett,
20. C. R. Hopkins,
21. A. Greka
, A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models. Science 358, 1332–1336 (2017).
OpenUrl Abstract/FREE Full Text
1. J.-J. Chung,
2. A. S. Shaw
, TRP’ing up chronic kidney disease. Science 358, 1256–1257 (2017).
OpenUrl Abstract/FREE Full Text

View Abstract

[1] Y. Zhou,
P. Castonguay,
E.-H. Sidhom,
A. R. Clark,
M. Dvela-Levitt,
S. Kim,
J. Sieber,
N. Wieder,
J. Y. Jung,
S. Andreeva,
J. Reichardt,
F. Dubois,
S. C. Hoffmann,
J. M. Basgen,
M. S. Montesinos,
A. Weins,
A. C. Johnson,
E. S. Lander,
M. R. Garrett,
C. R. Hopkins,
A. Greka
, A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models. Science 358, 1332–1336 (2017).
OpenUrl Abstract/FREE Full Text

[2] Y. Zhou,

[3] P. Castonguay,

[4] E.-H. Sidhom,

[5] A. R. Clark,

[6] M. Dvela-Levitt,

[7] S. Kim,

[8] J. Sieber,

[9] N. Wieder,

[10] J. Y. Jung,

[11] S. Andreeva,

[12] J. Reichardt,

[13] F. Dubois,

[14] S. C. Hoffmann,

[15] J. M. Basgen,

[16] M. S. Montesinos,

[17] A. Weins,

[18] A. C. Johnson,

[19] E. S. Lander,

[20] M. R. Garrett,

[21] C. R. Hopkins,

[22] A. Greka

[23] J.-J. Chung,
A. S. Shaw
, TRP’ing up chronic kidney disease. Science 358, 1256–1257 (2017).
OpenUrl Abstract/FREE Full Text

[24] J.-J. Chung,

[25] A. S. Shaw

Papers of note in Science 358 (6368)

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17 May 2019

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