19 December 2017
Vol 10, Issue 510

About The Cover

Cover image expansion

Online Cover This week features a Research Article that shows that reducing the strength of signaling by the cytokine interleukin-2 (IL-2) in T cells accelerates disease in a mouse model of type 1 diabetes. This was associated with a decrease in the numbers and suppressive activity of different regulatory T cell subsets in the pancreas. The image shows the infiltration of the mouse pancreas with autoreactive T cells. [Image: Dwyer et al./Science Signaling]