Contents
19 December 2017
Vol 10, Issue 510
Vol 10, Issue 510
Research Articles
- Altered homeostasis and development of regulatory T cell subsets represent an IL-2R–dependent risk for diabetes in NOD mice
Reducing IL-2 signaling in T cells results in accelerated diabetes in mice due to defective regulatory T cell function.
- IL-2Rβ abundance differentially tunes IL-2 signaling dynamics in CD4+ and CD8+ T cells
Receptor abundance determines the temporal signaling pattern and proliferative response in T cells stimulated with interleukin-2.
- mGluR5 antagonism increases autophagy and prevents disease progression in the zQ175 mouse model of Huntington’s disease
Inhibiting the glutamate receptor mGluR5 may prevent the progression of neuronal loss and motor impairment in patients with Huntington’s disease.
- Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT
Inhibition of the transporter xCT by oncogenic PI3K mutants contributes to methionine dependency in breast cancer cells.
Editors' Choice
- Highlight: IL-2 receptor signaling
Two papers reveal the consequences of altered interleukin-2 receptor signaling in T lymphocytes.
- Papers of note in Science 358 (6369)
This week’s articles explain why broad-leaved plants are susceptible to a microbial toxin that does not affect monocots; identify the enzymes that detyrosinate tubulin; and present synthetic biological systems for recording environmental signals and for translating a biochemical reaction into dynamic cellular behavior.
- Papers of note in Science Translational Medicine 9 (420)
This week’s articles describe ways to treat scleroderma and schizophrenia.
- Papers of note in Nature 552 (7684)
This week’s articles showed that enhancing a mitochondrial stress response reduced amyloid aggregation in mice; solved the structure of the ion channel TRPM4; found a role for NOTCH1 in the assembly of adherens junctions and endothelial barrier maintenance; and showed that RNA polymerase III limits life span in worms and flies.
About The Cover
Online Cover This week features a Research Article that shows that reducing the strength of signaling by the cytokine interleukin-2 (IL-2) in T cells accelerates disease in a mouse model of type 1 diabetes. This was associated with a decrease in the numbers and suppressive activity of different regulatory T cell subsets in the pancreas. The image shows the infiltration of the mouse pancreas with autoreactive T cells. [Image: Dwyer et al./Science Signaling]
