Papers of note in Science Translational Medicine 9 (420)

Leslie K. Ferrarelli

doi:10.1126/scisignal.aar6958

This week’s articles describe ways to treat scleroderma and schizophrenia.

FIBROSIS

Reversing fibrosis through apoptosis

Lagares et al. report that ABT-263 reverses dermal fibrosis in models of the fibrotic connective tissue disorder scleroderma by blocking the antiapoptotic protein BCL-X_L.

NEUROSCIENCE

Thorase ATPase, a multifunctional enzyme

Umanah et al. report that rare variants in the enzyme thorase increase the abundance of glutamate receptors in cortical neurons, resulting in behavioral abnormalities associated with schizophrenia that were reversed with the AMPA receptor antagonist Perampanel.

Highlighted Articles

1. D. Lagares,
2. A. Santos,
3. P. E. Grasberger,
4. F. Liu,
5. C. K. Probst,
6. R. A. Rahimi,
7. N. Sakai,
8. T. Kuehl,
9. J. Ryan,
10. P. Bhola,
11. J. Montero,
12. M. Kapoor,
13. M. Baron,
14. X. Varelas,
15. D. J. Tschumperlin,
16. A. Letai,
17. A. M. Tager
, Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis. Sci. Transl. Med. 9, eaal3765 (2017).
OpenUrl Abstract/FREE Full Text
1. G. K. E. Umanah,
2. M. Pignatelli,
3. X. Yin,
4. R. Chen,
5. J. Crawford,
6. S. Neifert,
7. L. Scarffe,
8. A. A. Behensky,
9. N. Guiberson,
10. M. Chang,
11. E. Ma,
12. J. W. Kim,
13. C. C. Castro,
14. X. Mao,
15. L. Chen,
16. S. A. Andrabi,
17. M. V. Pletnikov,
18. A. E. Pulver,
19. D. Avramopoulos,
20. A. Bonci,
21. D. Valle,
22. T. M. Dawson,
23. V. L. Dawson
, Thorase variants are associated with defects in glutamatergic neurotransmission that can be rescued by Perampanel. Sci. Transl. Med. 9, eaah4985 (2017).
OpenUrl FREE Full Text

View Abstract

[1] D. Lagares,
A. Santos,
P. E. Grasberger,
F. Liu,
C. K. Probst,
R. A. Rahimi,
N. Sakai,
T. Kuehl,
J. Ryan,
P. Bhola,
J. Montero,
M. Kapoor,
M. Baron,
X. Varelas,
D. J. Tschumperlin,
A. Letai,
A. M. Tager
, Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis. Sci. Transl. Med. 9, eaal3765 (2017).
OpenUrl Abstract/FREE Full Text

[2] D. Lagares,

[3] A. Santos,

[4] P. E. Grasberger,

[5] F. Liu,

[6] C. K. Probst,

[7] R. A. Rahimi,

[8] N. Sakai,

[9] T. Kuehl,

[10] J. Ryan,

[11] P. Bhola,

[12] J. Montero,

[13] M. Kapoor,

[14] M. Baron,

[15] X. Varelas,

[16] D. J. Tschumperlin,

[17] A. Letai,

[18] A. M. Tager

[19] G. K. E. Umanah,
M. Pignatelli,
X. Yin,
R. Chen,
J. Crawford,
S. Neifert,
L. Scarffe,
A. A. Behensky,
N. Guiberson,
M. Chang,
E. Ma,
J. W. Kim,
C. C. Castro,
X. Mao,
L. Chen,
S. A. Andrabi,
M. V. Pletnikov,
A. E. Pulver,
D. Avramopoulos,
A. Bonci,
D. Valle,
T. M. Dawson,
V. L. Dawson
, Thorase variants are associated with defects in glutamatergic neurotransmission that can be rescued by Perampanel. Sci. Transl. Med. 9, eaah4985 (2017).
OpenUrl FREE Full Text

[20] G. K. E. Umanah,

[21] M. Pignatelli,

[22] X. Yin,

[23] R. Chen,

[24] J. Crawford,

[25] S. Neifert,

[26] L. Scarffe,

[27] A. A. Behensky,

[28] N. Guiberson,

[29] M. Chang,

[30] E. Ma,

[31] J. W. Kim,

[32] C. C. Castro,

[33] X. Mao,

[34] L. Chen,

[35] S. A. Andrabi,

[36] M. V. Pletnikov,

[37] A. E. Pulver,

[38] D. Avramopoulos,

[39] A. Bonci,

[40] D. Valle,

[41] T. M. Dawson,

[42] V. L. Dawson

Papers of note in Science Translational Medicine 9 (420)

Highlighted Articles

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