This week’s articles describe ways to treat scleroderma and schizophrenia.
FIBROSIS
Reversing fibrosis through apoptosis
Lagares et al. report that ABT-263 reverses dermal fibrosis in models of the fibrotic connective tissue disorder scleroderma by blocking the antiapoptotic protein BCL-XL.
NEUROSCIENCE
Thorase ATPase, a multifunctional enzyme
Umanah et al. report that rare variants in the enzyme thorase increase the abundance of glutamate receptors in cortical neurons, resulting in behavioral abnormalities associated with schizophrenia that were reversed with the AMPA receptor antagonist Perampanel.