Papers of note in Nature 552 (7684)

John F. Foley

doi:10.1126/scisignal.aar7665

This week’s articles showed that enhancing a mitochondrial stress response reduced amyloid aggregation in mice; solved the structure of the ion channel TRPM4; found a role for NOTCH1 in the assembly of adherens junctions and endothelial barrier maintenance; and showed that RNA polymerase III limits life span in worms and flies.

ALZHEIMER’S DISEASE

Mitochondrial proteostasis and amyloid aggregation

Sorrentino et al. found that enhancing mitochondrial proteostasis reduced amyloid aggregation in mouse models of Alzheimer’s diease.

STRUCTURAL BIOLOGY

Revealing the architecture of TRPM4

Winkler et al. and Guo et al. used cryo–electron microscopy to solve the structure of the calcium-activated, nonselective ion channel TRPM4, providing insights into its function and pharmacology.

MECHANOTRANSDUCTION

Linking transcription programs with adhesion

Polacheck et al. showed that shear stress stimulates the formation of a NOTCH1-containing complex that stimulates adherens junction formation and the maintenance of endothelial barrier function.

AGING

Targeting RNA polymerase III to combat aging?

Filer et al. found that RNA polymerase III limits life span in worms and flies downstream of the kinase complex TORC1 (see also Edgar and Grewal).

Highlighted Articles

1. V. Sorrentino,
2. M. Romani,
3. L. Mouchiroud,
4. J. S. Beck,
5. H. Zhang,
6. D. D’Amico,
7. N. Moullan,
8. F. Potenza,
9. A. W. Schmid,
10. S. Rietsch,
11. S. E. Counts,
12. J. Auwerx
, Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity. Nature 552, 187–193 (2017).
OpenUrl
1. P. A. Winkler,
2. Y. Huang,
3. W. Sun,
4. J. Du,
5. W. Lü
, Electron cryo-microscopy structure of a human TRPM4 channel. Nature 552, 200–204 (2017).
OpenUrl PubMed
1. J. Guo,
2. J. She,
3. W. Zeng,
4. Q. Chen,
5. X. -c. Bai,
6. Y. Jiang
, Structures of the calcium-activated, non-selective cation channel TRPM4. Nature 552, 205–209 (2017).
OpenUrl
1. W. J. Polacheck,
2. M. L. Kutys,
3. J. Yang,
4. J. Eyckmans,
5. Y. Wu,
6. H. Vasavada,
7. K. K. Hirschi,
8. C. S. Chen
, A non-canonical Notch complex regulates adherens junctions and vascular barrier function. Nature 552, 258–262 (2017).
OpenUrl
1. D. Filer,
2. M. A. Thompson,
3. V. Takhaveev,
4. A. J. Dobson,
5. I. Kotronaki,
6. J. W. M. Green,
7. M. Heinemann,
8. J. M. A. Tullet,
9. N. Alic
, RNA polymerase III limits longevity downstream of TORC1. Nature 552, 263–267 (2017).
OpenUrl
1. B. A. Edgar,
2. S. S. Grewal
, Longer life through an odd Pol enzyme. Nature 552, 182–183 (2017).
OpenUrl

[1] V. Sorrentino,
M. Romani,
L. Mouchiroud,
J. S. Beck,
H. Zhang,
D. D’Amico,
N. Moullan,
F. Potenza,
A. W. Schmid,
S. Rietsch,
S. E. Counts,
J. Auwerx
, Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity. Nature 552, 187–193 (2017).
OpenUrl

[2] V. Sorrentino,

[3] M. Romani,

[4] L. Mouchiroud,

[5] J. S. Beck,

[6] H. Zhang,

[7] D. D’Amico,

[8] N. Moullan,

[9] F. Potenza,

[10] A. W. Schmid,

[11] S. Rietsch,

[12] S. E. Counts,

[13] J. Auwerx

[14] P. A. Winkler,
Y. Huang,
W. Sun,
J. Du,
W. Lü
, Electron cryo-microscopy structure of a human TRPM4 channel. Nature 552, 200–204 (2017).
OpenUrl PubMed

[15] P. A. Winkler,

[16] Y. Huang,

[17] W. Sun,

[18] J. Du,

[19] W. Lü

[20] J. Guo,
J. She,
W. Zeng,
Q. Chen,
X. -c. Bai,
Y. Jiang
, Structures of the calcium-activated, non-selective cation channel TRPM4. Nature 552, 205–209 (2017).
OpenUrl

[21] J. Guo,

[22] J. She,

[23] W. Zeng,

[24] Q. Chen,

[25] X. -c. Bai,

[26] Y. Jiang

[27] W. J. Polacheck,
M. L. Kutys,
J. Yang,
J. Eyckmans,
Y. Wu,
H. Vasavada,
K. K. Hirschi,
C. S. Chen
, A non-canonical Notch complex regulates adherens junctions and vascular barrier function. Nature 552, 258–262 (2017).
OpenUrl

[28] W. J. Polacheck,

[29] M. L. Kutys,

[30] J. Yang,

[31] J. Eyckmans,

[32] Y. Wu,

[33] H. Vasavada,

[34] K. K. Hirschi,

[35] C. S. Chen

[36] D. Filer,
M. A. Thompson,
V. Takhaveev,
A. J. Dobson,
I. Kotronaki,
J. W. M. Green,
M. Heinemann,
J. M. A. Tullet,
N. Alic
, RNA polymerase III limits longevity downstream of TORC1. Nature 552, 263–267 (2017).
OpenUrl

[37] D. Filer,

[38] M. A. Thompson,

[39] V. Takhaveev,

[40] A. J. Dobson,

[41] I. Kotronaki,

[42] J. W. M. Green,

[43] M. Heinemann,

[44] J. M. A. Tullet,

[45] N. Alic

[46] B. A. Edgar,
S. S. Grewal
, Longer life through an odd Pol enzyme. Nature 552, 182–183 (2017).
OpenUrl

[47] B. A. Edgar,

[48] S. S. Grewal

Papers of note in Nature 552 (7684)

Highlighted Articles

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