Contents
02 January 2018
Vol 11, Issue 511
Vol 11, Issue 511
Editorial Guide
- Predicting the future of signaling for 2018
Science Signaling Chief Scientific Editor Michael B. Yaffe looks forward to what this year has in store for signaling research.
Research Articles
- Blockade of TNFR2 signaling enhances the immunotherapeutic effect of CpG ODN in a mouse model of colon cancer
Blocking the tumor necrosis factor receptor TNFR2 enhances cancer immunotherapy by selectively suppressing tumor-associated regulatory T cells.
- The depalmitoylase APT1 directs the asymmetric partitioning of Notch and Wnt signaling during cell division
Palmitoylation-dependent asymmetric partitioning of cell fate determinants correlates with tumor cell heterogeneity.
- The endoplasmic reticulum–residing chaperone BiP is short-lived and metabolized through N-terminal arginylation
N-terminal arginylation in response to various stresses causes the ER chaperone BiP to relocate to and be degraded in the cytosol.
Review
- Structural principles of tumor necrosis factor superfamily signaling
Insights into the resting and active state structures of TNF superfamily receptors reveal opportunities for drug development.
Editors' Choice
- New connections: Stimulating immune memory against cancer
Future immunotherapies may stimulate immune system attack as well as memory against cancer to prevent relapse in patients.
About The Cover
Online Cover This week features a Review that discusses how new structural details of the tumor necrosis factor (TNF) superfamily may enable development of better-targeted therapeutics. The image depicts the hexagonal lattice structure of the TNF superfamily. [Image: Éva S. Vanamee and Denise L. Faustman, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA]