The endoplasmic reticulum–residing chaperone BiP is short-lived and metabolized through N-terminal arginylation

Sang Mi Shim; Ha Rim Choi; Ki Woon Sung; Yoon Jee Lee; Sung Tae Kim; Daeho Kim; Su Ran Mun; Joonsung Hwang; Hyunjoo Cha-Molstad; Aaron Ciechanover; Bo Yeon Kim; Yong Tae Kwon

doi:10.1126/scisignal.aan0630

Research ArticleStress responses

The endoplasmic reticulum–residing chaperone BiP is short-lived and metabolized through N-terminal arginylation

View ORCID ProfileSang Mi Shim¹,²,
Ha Rim Choi¹,²,
View ORCID ProfileKi Woon Sung¹,²,
View ORCID ProfileYoon Jee Lee¹,²,
View ORCID ProfileSung Tae Kim¹,²,³,
Daeho Kim¹,⁴,
View ORCID ProfileSu Ran Mun¹,²,
Joonsung Hwang⁵,
View ORCID ProfileHyunjoo Cha-Molstad⁵,
View ORCID ProfileAaron Ciechanover¹,⁶,
View ORCID ProfileBo Yeon Kim⁵,*, and
View ORCID ProfileYong Tae Kwon¹,²,⁷,*

¹Protein Metabolism Medical Research Center, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.
²Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.
³Center for Pharmacogenetics and Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA.
⁴Department of Biophysics and Chemical Biology, College of Natural Sciences, Seoul National University, Seoul 08826, Republic of Korea.
⁵World Class Institute, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon 28116, Republic of Korea.
⁶Tumor and Vascular Biology Research Center, Rappaport Faculty of Medicine and Research Institute, Technion–Israel Institute of Technology, Haifa 31096, Israel.
⁷Ischemic/Hypoxic Disease Institute, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.

↵*Corresponding author. Email: yok5{at}snu.ac.kr (Y.T.K.); bykim{at}kribb.re.kr (B.Y.K.)

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Science Signaling 02 Jan 2018:
Vol. 11, Issue 511, eaan0630
DOI: 10.1126/scisignal.aan0630

Sang Mi Shim

1Protein Metabolism Medical Research Center, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.

2Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.

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ORCID record for Sang Mi Shim

Ha Rim Choi

1Protein Metabolism Medical Research Center, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.

2Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.

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Ki Woon Sung

1Protein Metabolism Medical Research Center, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.

2Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.

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Yoon Jee Lee

1Protein Metabolism Medical Research Center, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.

2Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.

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Sung Tae Kim

1Protein Metabolism Medical Research Center, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.

2Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.

3Center for Pharmacogenetics and Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA.

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Daeho Kim

1Protein Metabolism Medical Research Center, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.

4Department of Biophysics and Chemical Biology, College of Natural Sciences, Seoul National University, Seoul 08826, Republic of Korea.

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Su Ran Mun

1Protein Metabolism Medical Research Center, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.

2Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.

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Joonsung Hwang

5World Class Institute, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon 28116, Republic of Korea.

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Hyunjoo Cha-Molstad

5World Class Institute, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon 28116, Republic of Korea.

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ORCID record for Hyunjoo Cha-Molstad

Aaron Ciechanover

1Protein Metabolism Medical Research Center, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.

6Tumor and Vascular Biology Research Center, Rappaport Faculty of Medicine and Research Institute, Technion–Israel Institute of Technology, Haifa 31096, Israel.

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Bo Yeon Kim

5World Class Institute, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon 28116, Republic of Korea.

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For correspondence: yok5@snu.ac.kr bykim@kribb.re.kr

Yong Tae Kwon

1Protein Metabolism Medical Research Center, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.

2Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.

7Ischemic/Hypoxic Disease Institute, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.

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ORCID record for Yong Tae Kwon
For correspondence: yok5@snu.ac.kr bykim@kribb.re.kr

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The endoplasmic reticulum–residing chaperone BiP is short-lived and metabolized through N-terminal arginylation

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