Research ArticleCancer Immunotherapy
Blockade of TNFR2 signaling enhances the immunotherapeutic effect of CpG ODN in a mouse model of colon cancer
- Yingjie Nie1,2,
- Jiang He3,
- Hidekazu Shirota1,
- Anna L. Trivett1,
- De Yang1,
- Dennis M. Klinman1,
- Joost J. Oppenheim1,*, and
- Xin Chen3,1,*
- 1Cancer Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
- 2Department of Research, Guizhou Provincial People’s Hospital, Guiyang, Guizhou 550002, China.
- 3State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR 999078, China.
- ↵*Corresponding author. Email: xchen{at}umac.mo (X.C.); oppenhej{at}mail.nih.gov (J.J.O.)
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Science Signaling 02 Jan 2018:
Vol. 11, Issue 511, eaan0790
DOI: 10.1126/scisignal.aan0790